Kırşehir Ahi Evran Üniversitesi Kurumsal Akademik Arşivi
DSpace@Kırşehir, Kırşehir Ahi Evran Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve yayınların etkisimi artırmak için telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Impaired dynamic balance and its association with shoulder external rotation in patients with frozen shoulder: a cross-sectional study
(BioMed Central Ltd, 2026) Turhan, Atahan; Ceylan, İsmail; Özçelep, Ömer Faruk; Karaçam, Seher; Karaçay, Başak Çiğdem
Background: Frozen shoulder (FS) causes shoulder pain and limited range of motion, leading to functional deficits such as impaired balance, but the factors associated with balance in FS and differences from healthy individuals remain unclear. This study aimed to compare balance performance between FS patients and healthy controls and identify variables associated with balance using regression analysis. Methods: This cross-sectional study included 154 individuals aged 40–65, with 78 patients diagnosed with FS and 76 healthy controls. The static and dynamic balance of all participants was assessed using the Biodex Balance System. In the FS group, scapular dysfunction was assessed using the Lateral Scapular Slide Test, trunk control was evaluated using the Functional Reach Test, pain intensity was measured using the Visual Analogue Scale, pain duration and shoulder range of motion were also recorded. Independent Samples T-Tests were conducted to compare the groups, while Pearson Correlation and Simple Linear Regression Analyses were performed to identify factors associated with balance performance. Results: Dynamic balance was significantly impaired in individuals with FS compared to healthy controls (Dynamic Overall Stability Index [DOSI]: 3.44 ± 1.42 vs. 1.54 ± 1.08, MD 1.90 [95% CI: 1.51–2.30]; Dynamic Antero-Posterior Stability Index [DAPSI]: 3.29 ± 1.28 vs. 1.60 ± 1.10, MD 1.69 [95% CI: 1.30–2.07]; Dynamic Medio-Lateral Stability Index [DMLSI]: 3.18 ± 1.07 vs. 1.61 ± 1.03, MD 1.57 [95% CI: 1.23–1.90]; all p < 0.001). Regression analysis showed that external rotation angle (ERA) was a significant predictor negatively associated with DOSI (B= -0.046, 95% CI: − 0.081 to − 0.011, β= -0.290, p = 0.010), accounting for 8.4% of the variance observed. Conclusions: Dynamic balance is impaired in patients with FS compared to healthy controls, and shoulder ERA is a significant variable associated with DOSI
A Plant-Diversity Dark Spot at the Intersection of Three Biodiversity Hotspots: Environmental Drivers of Brassicaceae Richness in Türkiye
(John Wiley and Sons Ltd, 2026) Dumlupınar, İlayda; Özüdoğru, Barış; Gür, Hakan
[Abstract Not Available]
Evaluation of pyrimidine-based compounds as AChE and BChE inhibitors: in vitro inhibition, molecular modeling, and statistical evaluation
(Springer Science and Business Media Deutschland GmbH, 2026) Alım, Zuhal; Demir, Yeliz
Alzheimer’s disease (AD) is a neurodegenerative disease characterized by dementia, particularly in older adults. It is a process that is increasing significantly with the aging population worldwide, has yet to be cured, and therefore challenges healthcare systems. The ability of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors to modulate neurotransmitter levels has made AChE/BChE inhibitors central therapeutic targets in drug development studies for the treatment of AD. Previous studies have demonstrated the beneficial effects of pyrimidine derivatives on cognitive functions and highlighted their high therapeutic potential against neurodegenerative diseases. Considering the pharmacological importance of AChE/BChE inhibitors and pyrimidine derivatives, this study investigated the inhibitory potential of seven different pyrimidine derivatives (1–7) on AChE and BChE using both in vitro and in silico approaches. Analysis of IC50 values indicated that compounds 1–7 (IC50: 14.89–77.70 nM) exhibited strong inhibitory effect. Compound 6 (IC50:14.89 nM) had the strongest inhibitory effect on AChE, while it showed a much weaker inhibitory effect against BChE (IC50: 357 nM), corresponding to an approximately 24-fold selectivity for AChE. Molecular modeling results indicate that compounds 6 and 7 exhibit favorable interactions within the active site of the enzyme. In addition, compounds 1 and 3, which exhibited the strongest inhibitory effects on BChE, appear to display a multiple binding profile with the active site of BChE. Correlation and regression analyses indicated that compounds 1–7 display a structure–activity relationship (SAR) consistent with strong inhibitory potency toward AChE, while showing comparatively weaker inhibition toward BChE.
Low back pain, quality of life, and functional disability among drivers and nurses working in home healthcare services: a cross-sectional study
(BioMed Central Ltd, 2026) Ergün, Ali; Özçelep, Ömer Faruk; Berg, Ayşe Nur Tunali Van Den
Background: Low back pain (LBP) is a prevalent issue among workers in physically demanding occupations, including drivers and nurses. This study aims to evaluate the severity of low back pain, its impact on quality of life, and functional disability among drivers and nurses working in home healthcare services. Methods: This observational, descriptive, and analytical study was conducted with 100 participants (50 drivers and 50 nurses) working in home healthcare services. Pain severity was assessed using the Visual Analog Scale (VAS), functional disability using the Oswestry Disability Index (ODI), and quality of life using the Short Form-36 Health Survey (SF-36). Differences between groups were analyzed using independent t-tests and Mann-Whitney U tests. Analysis of Covariance (ANCOVA) was performed to control for age, sex, and BMI, while multiple linear regression was used to identify predictors of disability scores (p < 0.05). Results: Drivers had significantly higher mean age, height, and weight compared to nurses (p < 0.05), while Body Mass Index (BMI) was similar between groups (p > 0.05). No statistically significant differences were observed between the groups regarding pain intensity (VAS), disability level (ODI), and quality of life (SF-36) subscales. ANCOVA for age, sex, and BMI confirmed no significant effect of occupational group on clinical outcomes. Multiple regression analysis revealed that pain intensity during activity, rather than the occupational group, was the strongest predictor of disability level (p < 0.001). Conclusion: Nurses and drivers working in home healthcare services exhibited comparable levels of low back pain severity, functional disability, and quality of life. Pain intensity during activity, rather than occupational role, emerged as the primary determinant of functional disability. Clinical trial: Not Applicable.
Sex Estimation Using Cephalometric Data in a Turkish Population: A Logistic and ROC-Based Analysis
(Universidad de la Frontera, 2025) Alkan, Yarenkür
Sex estimation is a fundamental task in biological anthropology; however, most previous studies rely on skeletal collections or radiological data. This study is distinctive in its use of cephalometric measurements collected from living individuals to develop a population-specific sex estimation model based solely on head dimensions in a contemporary Turkish cohort. This approach offers a soft-tissue-based, population-specific model that may be useful in certain forensic screenings or clinical anthropological applications where skeletal data or imaging are not available. Although advanced imaging technologies such as CT and 3D scanning have become increasingly popular for metric analysis, they are often inaccessible in many contexts. Fourteen standardized cephalometric measurements were taken from a total of 244 adult individuals (128 males, 116 females). Both univariate and multivariate logistic regression models were constructed to evaluate sex estimation accuracy, while Receiver Operating Characteristic (ROC) analysis was used to assess model performance and identify optimal classification thresholds. The final multivariate model, which included maximum head breadth, total facial height, maximum head length, head circumference, nasal aperture breadth, and bigonial breadth, achieved an overall classification accuracy of 89.8 %, with a sensitivity of 89.84 %, specificity of 93.10 %, and an AUC of 0.965. These results demonstrate the strong discriminative power of the model and highlight the effectiveness of integrating cephalometric data with logistic regression and ROC analysis. By establishing population-specific threshold values, this study offers a robust and replicable framework for sex estimation applicable in both forensic and archaeological contexts. The findings also emphasize the value of accessible and cost-effective methods, particularly for use in resource-limited environments. Further research with larger and more diverse samples is encouraged to validate and broaden the applicability of these standards.
