Kırşehir Ahi Evran Üniversitesi Kurumsal Akademik Arşivi
DSpace@Kırşehir, Kırşehir Ahi Evran Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve yayınların etkisimi artırmak için telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Narrative Pedagogies in Cranial Nerve Anatomy: Comparing Mythological and Sports-Based Approaches with Traditional Teaching
(John Wiley and Sons Inc, 2026) Yılmaz, Halil; Polat, Dilber
This study used a mixed methods randomized controlled experimental design to evaluate the effectiveness of narrative-based versus traditional pedagogy in teaching cranial nerve anatomy to medicine students. Eighty-eight students who had completed a previous course on the nervous system were randomized into three groups: a control group receiving standard theoretical and practical anatomy instruction, a group using a mythological narrative (“Supper of Gods”), and a group using an animated sports-themed narrative (“Head Coach Hypoglossus”). Knowledge acquisition was assessed using pre- and post-intervention multiple choice tests, while qualitative data were collected using structured interviews in the narrative groups. Results showed no significant baseline differences between groups. Although all groups improved after training, only the Head Coach Hypoglossus group showed significantly higher post-test scores (mean 13.13 ± 1.73) compared with the control (10.39 ± 3.89) and mythological narrative (10.86 ± 2.54) groups (p < 0.01). Qualitative analysis revealed that most students in the narrative groups reported improved memorization, short-term recall, and motivation, with 62% citing easier recall and 68% describing increased engagement. However, some students found story creation challenging (45%) or time-consuming (38%), and a minority felt that the narrative approach could distract from the core content. In conclusion, the integration of animated, character-driven narratives (particularly the sports-themed approach) significantly improved short-term learning outcomes and student engagement compared to traditional and myth-based methods.
Coloration Mechanisms of Paleozoic Marbles of Central Anatolia: Mineralogical and Geochemical Evidence from White, Blue, and Grayish-Blue Calcites, Kırşehir, Türkiye
(Multidisciplinary Digital Publishing Institute (MDPI), 2026) Başıbüyük, Zeynel; Kaydu Akbudak, İlkay
Blue calcite mineral formations occurring within Paleozoic marbles of Central Anatolia have been investigated in terms of their mineralogical and geochemical characteristics, as well as their potential for use as ornamental stones or decorative objects. XRD analyses of samples with different color tones (white, grayish-blue, and blue) revealed that the white sample contains only calcite, the grayish-blue samples include calcite and dolomite, while the blue sample contains calcite and quartz. XRF and ICP-MS analyses indicate a marked enrichment of trace elements such as Fe, Cr, and Ni in the blue sample, and Mn and Fe in the grayish-blue samples, suggesting these elements may influence the observed color variations. The presence of dolomite in grayish-blue samples and quartz in the blue sample corresponds to elevated MgO and SiO2 contents, respectively. Based on their distinct colors, textures, transparency, and other aesthetic properties, the grayish-blue and blue marbles show significant potential for use as decorative stones or ornamental objects.
Prognostic Significance of the C-Reactive Protein–Albumin–Lymphocyte İndex and The Pan-İmmune-İnflammation Value in İschemic and Hemorrhagic Stroke: A Comparative Analysis of Subtypes
(Frontiers Media SA, 2026) Şahin, Canan; Şahin, Yahya
Background: Cerebrovascular events are major causes of global mortality and disability. Inflammation, immune response, and nutritional status play crucial roles in stroke pathophysiology. The C-reactive protein–albumin–lymphocyte (CALLY) index and the pan-immune-inflammation value (PIV) are novel composite biomarkers reflecting these mechanisms. This study compared their prognostic performance between ischemic and hemorrhagic stroke. Methods: This retrospective, single-center cohort included 357 patients diagnosed with ischemic or hemorrhagic stroke between January 2020 and December 2024. Demographic, clinical, and laboratory data were retrieved from electronic records. Indices including CALLY, PIV, HALP, SII, and MII were calculated from blood samples obtained within 24 h of admission. Group comparisons, multivariate logistic regression, and receiver operating characteristic (ROC) analyses identified independent predictors and diagnostic performance. Results: Among 357 patients (mean age 67 ± 14 years; 56.6% ischemic, 43.4% hemorrhagic), the CALLY index was significantly higher in hemorrhagic cases (p < 0.001). Multivariate analysis identified CALLY (odds ratio = 1.255), PIV (odds ratio = 1.001), and HALP (odds ratio = 1.258) as independent predictors (all p < 0.001). CALLY showed the highest discriminative ability (area under the ROC curve = 0.756). In hemorrhagic stroke, lower CALLY values were associated with in-hospital mortality (AUC = 0.646, p = 0.002). Conclusion: The CALLY index demonstrated superior prognostic value compared with other inflammatory markers and may serve as a simple, low-cost tool for early stroke risk assessment. Prospective, multicenter studies are warranted to validate these findings and to establish standardized cutoff values.
Synthesis, Antimicrobial Evaluation, and Molecular Docking Analysis of Novel Schiff Bases Derived from Isatoic Anhydride and Salicylaldehyde
(Multidisciplinary Digital Publishing Institute (MDPI), 2026) Tunç, Turgay; Köse, Yaşar
Schiff bases are bioactive compounds that have been synthesized by many researchers in recent years. They may also exhibit strong antimicrobial activities against various pathogenic microorganisms in both medicine and veterinary applications. The synthesis of new Schiff base-derived compounds remains of interest due to the increasing problem of antibiotic-resistance in clinical practice. Seven new Schiff base derivatives were synthesized, and their chemical structures were characterized using FT-IR, 1H/13C NMR, and LCMS-MS analyses. The antimicrobial activities of thesyntesized compounds against various pathogenic bacteria, yeasts, and fungi were evaluated using the disk-diffusion method, and their MIC values were also determined. In addition, one representative microorganisms from each class were selected for molecular docking studies. IFD analyses were performed for the 4f and 4g ligands using the dihydrofolate reductase enzyme. Spectroscopic analyses confirmed the structures of the synthesized compounds, revealing the presence of characteristic imine functionalities and validating the integrity of the molecular frameworks. Antimicrobial assays demonstrated that several derivatives exhibited measurable activity, with compounds 4f and 4g showing the most potent effects, displaying MIC values of 32 µg/mL against B. cereus and E. faecalis, respectively. Molecular docking studies further indicated that both 4f and 4g bind efficiently to the DHFR active site. These findings indicate that among the synthesized Schiff base derivatives, compounds 4f and 4g exhibit particularly promising antimicrobial activity, warranting further pharmacological evaluation and medicinal chemistry optimization.
Interpreting Linear Enamel Hypoplasia at the Amastris (Ağlayan Ağaç) Chapel Cemetery From the Eastern Roman Imperial Period Region of Paphlagonia (Türkiye)
(John Wiley and Sons Ltd, 2026) Taş, Ali; Şener, Elçin; Erkman, Ahmet Cem
Abstract
The aim of this study is to evaluate the values of linear enamel hypoplasia (LEH) observed in the permanent teeth of individuals excavated from a chapel site dated to the Late Eastern Roman Period (6th–9th centuries) through analytical methods. The study is based on LEH findings identified in 148 (37.4%) of 396 permanent teeth belonging to 30/54 individuals. LEH measurements were conducted using two well-established methodologies documented in the literature. The prevalence of LEH suggests that the onset of the weaning process in infancy or early childhood coincided with the emergence of disease-inducing factors, estimated to occur between the ages of 3.5 and 5 years. Comparative evaluation of the two methodological approaches revealed consistent and convergent findings. It is hypothesized that a combination of factors including metabolic disorders, pathological conditions, environmental influences, socialization patterns, poor hygiene, nutritional deficiencies, and suboptimal living conditions contributed to heightened disease susceptibility during the weaning phase. This study presents the first LEH dataset from the Western Black Sea (Paphlagonia) region of Türkiye and contextualizes the findings through comparisons with other coastal harbor communities previously examined in a limited capacity. This research focuses on a comprehensive analysis to help create a more chronological and geographical comprehensive LEH dataset of ancient Anatolian societies in later periods.
