Kırşehir Ahi Evran Üniversitesi Kurumsal Akademik Arşivi
DSpace@Kırşehir, Kırşehir Ahi Evran Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve yayınların etkisimi artırmak için telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
The Effect of Carvacrol on Kidney İnjury Caused By İsopreterenol-İnduced Myocardial İnfarction
(BioMed Central Ltd, 2025) Ünlü, Gülhan; Yıldız, Halime Tozak; Yıldız, Osman Mert
Background: Myocardial infarction is a major cause of morbidity and mortality, often leading to heart and kidney dysfunction. Despite advancements in treatment, the link between heart and kidney damage is poorly understood. This study aims to evaluate the potential protective effect of Carvacrol, a natural bioactive compound, on kidney injury induced by myocardial infarction. Methods: In this experimental study, 32 male Wistar rats were divided into four groups: Control, Carvacrol (50 mg/kg), Myocardial Infarction (85 mg/kg isoproterenol), and Myocardial Infarction + Carvacrol (50 mg/kg Carvacrol + 85 mg/kg isoproterenol). Carvacrol was administered for six weeks, and myocardial infarction was induced with isoproterenol. Blood pressure, biochemical parametres (creatinin kinase, lactate dehydrogenase, urea, creatinine, GDF-15, IL-6), and kidney tissue histopathology were evaluated. Results: Biochemical analysis showed increased Creatinin Kinase and Lactate Dehydrogenase levels in the Myocardial Infarction group compared to controls(p = 0.023, p = 0.020), with carvacrol reducing these markers. IL-6 and GDF-15 levels were elevated in both the Myocardial Infarction and Myocardial Infarction + Carvacrol groups (p = 0.009, p < 0.001). Blood pressure was significantly reduced in the Myocardial Infarction group. Histopathological examination revealed severe kidney damage in the Myocardial Infarction group, while Carvacrol treatment showed less kidney damage, with only mild tubular dilation and rare necrosis. Conclusion: Carvacrol appears to have protective effects against kidney injury in myocardial infarction. It reduced myocardial injury markers and kidney damage, suggesting its potential therapeutic use in cardiorenal syndrome. Further studies are needed to understand its mechanisms and clinical applications in cardiovascular and renal diseases.
Intercalary Autograft Not Mandatory for Shortening in Total Hip Arthroplasty: A Retrospective Study
(Elsevier B.V., 2026) Çakmak, Mehmet Fevzi; Bayram, Serkan; Horoz, Levent; Sezgin, Hicabi; Akan, Burak
Background: This study aimed to compare the clinical and radiological outcomes of patients who underwent autograft application following standard transverse osteotomy supported by two cobalt-chrome cables with those who did not use autografts to support the osteotomy line in Crowe type IV Developmental Dysplasia of the Hip (DDH). Methods: Sixty-nine patients (78 hips) with Crowe type IV DDH underwent a transverse subtrochanteric shortening osteotomy. In Group 1, 42 hips had their osteotomy site supported with an autograft harvested from the shortening osteotomy. Conversely, Group 2 consisted of 36 hips in which graft application was not performed, and fixation of the osteotomy site was solely achieved by employing the femoral stem. Clinical outcome measures included limb length discrepancy, pain (visual analog score), and functional Harris Hip Score (HHS). For radiological evaluation, bone healing of the femoral osteotomy site was assessed using the radiographic union score for tibial (mRUST) classification, and stabilization of components was evaluated according to the Engh classification. Results: There were no significant differences in age, body mass index, follow-up duration, preoperative and postoperative LLD, VAS score, and HHS values. No statistically significant difference was identified between the Engh classification. Significant differences between the groups were detected in the mRUST classification (p = 0.020). The mean value of the group not utilizing autograft (11,89 ± 1,83) was higher than that of the group using autografts (10,95 ± 1,59). There was no statistically significant relationship between complications between the groups (p = 0.981). Conclusion: Performing of THA in Crowe type IV DDH, the press-fit application of the femoral component, without additional implantation or grafting, have shown comparable and satisfactory outcomes.
Identification of Additional Probiotic Attributes in Yeasts İsolated from Tarhana Fermentation
(Springer Nature, 2025) Erdem, Belgin; Kaya, Halil İbrahim; Tulumoğlu, Şener; Çöteli, Ebru; Şimşek, Ömer
Fermented foods constitute a valuable source of probiotics for both bacteria and yeasts. To date, however, there has been a limited amount of research conducted on Saccharomyces cerevisiae, Kazakhstania servazzi, Kluyveromyces marxianus and Torulaspora delbrueckii isolated from tarhana. The objective of the research is to identify additional probiotic characteristics other than the leavening activity exhibited by yeasts that were previously isolated from tarhana fermentation. In this study, yeasts were subjected to subsequent acid and bile salt tolerance, bile salt hydrolysis, antagonistic activity, aggregation activity (auto-aggregation and co-aggregation), cholesterol assimilation, folate production, biofilm production, and hemolysis activity. S. cerevisiae PCF122, S. cerevisiae PCF107, and S. cerevisiae PCF134 strains grew at pH 2 and 2,5 but remained at pH 3. Except for S. cerevisiae PCF115 and T. delbrueckii PCF150, all yeasts were found to be 0,5% and 1,0% oxalate tolerant. All yeasts hydrolyze oxalate (bile salt), but only S. cerevisiae PCF115 and T. delbrueckii PCF150 produced EPS. Yeasts also exhibited significant amounts of autoaggregation (46–87%). After 24 and 48 h incubation, all strains assimilated cholesterol at rates ranging from 10,4% to 87,5% and 10,6–91%, respectively. The highest folate production was determined at S. cerevisiae PCF108 (56 µg/mL) and the lowest was at S. cerevisiae PCF110 and K. marxianus PFC120 (18 µg/mL). In conclusion, yeasts that existed in tarhana fermentation showed cholesterol assimilation, folate production, and aggregation activity which are additional probiotic attributes that would have consumer health promotion, beside these yeast leaven the tarhana dough.
On Influence of Fluid Viscosity on Interface Pressure in Hydro-Piezoelectric System Under Its Forced Vibration
(Springer, 2025) Akbarov, S.D.; Ekicioğlu, Küzeci Zeynep
The primary focus of this paper is to examine the effect of fluid viscosity on vibration that occurs when harmonic mechanical force is applied to a system consisting of a piezoelectric plate, a compressible viscous fluid, and a rigid wall. The exact equations of motion of the linear electro-elasticity theory for the piezoelectric materials are used to describe the plate motion. The plane-strain state of the plate is considered. The linearized Navier-Stokes equations for a compressible (barotropic) viscous fluid are used to describe the fluid flow, and the plane flow is taken into consideration. Equations corresponding to the problem are solved by applying the Fourier transform with respect to the space coordinate, which is on the coordinate axis directed along the plate-lying direction. The Fourier transforms are determined analytically, but the inverse transforms are computed numerically. Numerical results on the interface pressure are obtained for the PMN-PT and PZT-2 materials, and the results are discussed. According to these results, it is established that the fluid viscosity causes the increase in the amplitude of the interface normal stress and can also significantly affect the vibration phase at which the studied stress has its absolute minimum value. Furthermore, the electromechanical coupling effects of the plate material on the studied parameters are determined.
Unveiling Turkish Students’ Global Competence: A Psychometric Network Analysis of PISA 2018 Data
(Routledge, 2025) Kuş, Zafer; Demirkol, Sinem; Elvan, Özlem
This study aims to examine the interactions between ten scales representing different aspects of the global competence model among students in Turkey, based on PISA 2018 data. The study analyses data from 6,731 students in Turkey who participated in the global competence survey using the psychometric network approach, which is often used to explore relationships between psycho-behavioral structures. The results show that students’ global competence in Turkey involves complex and multidimensional relationships. A strong relationship was found between students’ awareness of global issues and their ability to discuss complex global issues, as well as between their interest in learning about other cultures and their respect for people from different cultural backgrounds.
