Kırşehir Ahi Evran Üniversitesi Kurumsal Akademik Arşivi
DSpace@Kırşehir, Kırşehir Ahi Evran Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve yayınların etkisimi artırmak için telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Effects of 24-bp Indel Mutation Within the AHR Gene on Litter Size in the Akkaraman Sheep Breed
(Ankara University, 2025) Soydan, Ercan; Kırıkçı, Koray
The aryl hydrocarbon receptor (Ahr) is a transcription factor that is involved in a variety of biological processes, such as cell proliferation, growth and the immune system. Previous investigations have asserted the importance of Ahr gene in female reproduction. However, there are limited studies on the exact mechanisms of the Ahr gene on sheep litter size. Therefore, this study aimed to investigate the 24-bp indel mutation in region 3 of the Ahr gene in Akkaraman sheep, and its impact on litter size. A total of 100 blood samples were used for the study. Genomic DNA was obtained from whole blood. Following the polymerase chain reaction (PCR) analysis, all animals were genotyped based on the result of the agarose gel image. In the study, a 24-bp indel mutation was found, and tree genotypes (II, ID and DD) were detected in Akkaraman sheep. The ID (Insertion/deletion) genotype (59%) was the most common, followed by DD (deletion/deletion) (36%) and II (Insertion/insertion) (5%). In addition, the association analyses showed that the indel mutation within the Ahr gene had a significant influence on litter size.
The Influence of Abdulhamid II’s Relationship with Pasteur and the Pasteur Institute on Ottoman Medicine
(Istanbul Universitesi, 2025) Nizamoğlu, Ahmet; Köken, Arif Hüdai; İlter, Hüseyin
Abdülhamid II’s interest in medicine and health initiated relations with Louis Pasteur. The scientific contacts and achievements established on this axis were turned into a policy by order of the sultan. The interaction between Abdülhamid II and Pasteur, which started in the last quarter of the 19th century, can be said to have created an infrastructure for the current scientifically based health policies in terms of public health and preventive medicine practices that have continued from the Ottoman Empire to the present day. The process initiated by Abdülhamid II, in line with his relations with Pasteur and the Pasteur Institute, paved the way for a more effective fight against other infectious diseases such as rabies, anthrax, smallpox, and diphtheria. In this study, Abdülhamid II’s relations with Pasteur and the Pasteur Institute, which formed the basis of modern public health policies, were evaluated in the light of archival documents, printed works, periodicals, statistical reports, and copyrighted works. The study was conducted using the survey model and document analysis method
Revealing The Potential of Double Perovskite Hydrides A2sih6 (A = Li and Na) for Solid-State Hydrogen Storage Applications
(Elsevier Ltd, 2025) Candan, Abdullah; Erkisi, Aytaç; Yıldız, Buğra
Hydrogen's potential as a clean energy source has made hydrogen storage a critical focus of modern research. Among candidate materials, advanced double perovskite hydrides have emerged as promising options for hydrogen storage applications due to their structural versatility and favorable physical properties. In this study, a comprehensive first-principles analysis was conducted to investigate the structural, mechanical, electronic, and hydrogen storage characteristics of A2SiH6 (A = Li and Na) double perovskite-type hydrides. The calculated tolerance factors indicate that both hydrides possess stable cubic perovskite structures, while their negative enthalpy of formation further validates their thermodynamic stability. Moreover, the AIMD simulations were performed to investigate the thermal stability of these compounds. Electronic band structure calculations revealed that both Li2SiH6 and Na2SiH6 exhibit semiconducting behavior, with indirect band gaps calculated as 1.28 eV and 1.44 eV using GGA-PBE, and 2.22 eV and 2.32 eV using the more accurate HSE06 functional, respectively. Moreover, their mechanical stability is confirmed by compliance with Born's criteria, suggesting their robustness under operational conditions. In addition to these properties, hydrogen storage capacity evaluations demonstrated significant gravimetric hydrogen contents of 12.60 wt% for Li2SiH6 and 7.55 wt% for Na2SiH6, indicating their potential as high-capacity hydrogen storage materials. Furthermore, dielectric constant, refractive index, and absorption coefficient calculations were performed to fully characterize their electronic behavior. Overall, these results suggest that A2SiH6 (A = Li and Na) hydrides are promising candidates for hydrogen storage applications, supported by their favorable tolerance factors, structural stability, electronic properties, and thermodynamic features.
Effects of 2100 Mhz Radio-Frequency Fields on Brain Tissues and Plasma of Normal Rats and Obese Rats
(Taylor and Francis Ltd., 2025) Günay, Sevilay; Delen, Kevser; Özkan, Enis Taha; Kuzay Aksoy, Dilek; Sırav Aral, Bahriye
The use of mobile phones, one of the popular recent sources of radio-frequency fields (RFF), is increasing. It has been shown thatRFF exposure can increase free radical levels and oxidative stress.Obesity is an important risk factor for many diseases such as cancer, cardiovascular diseases, and diabetes, and has been shown to increase oxidative stress. In this study, rats were exposed to 2100 MHz RFF(electric field 15 V/m) for 15 minutes daily and 4 hours daily for 3 weeks. It aims to investigate the effects of 2100 MHz RFF on brain tissue and plasma of normal and obese rats. The rats were divided into eight groups (n = 6):control, Sham1, Sham2, RFF1, RFF2, High Fat Diet (HFD), Sham+HFD, andHFD+RFF. The inflammatory and oxidative effects on brain tissue and plasma were analyzed using the GraphPad 9 macOS package program. WhenTOS levels in brain tissue were compared between Sham2 and RFF1 andall groups, a significant difference was found in the RFF2 group. TASlevel was significantly different in the HDF+RFF group compared to the control group, Sham and all groups. When pro-inflammatory and anti-inflammatory parameters were evaluated in brain tissue, significant differences were found in different exposure groups. Inplasma, TOS levels were significantly different in the RFF2 groupcompared to Sham2 and RFF1, but TAS levels were not different.According to the data obtained, obesity may be protective against the oxidative and inflammatory effects of RFF.
Cmıp6 İklim Değişikliği Senaryoları Altında Taşkın Frekans Analizi: Rüstemgedik Köprüsü (Muş) Örneği
(Kırşehir Ahi Evran Üniversitesi, Fen Bilimleri Enstitüsü, 2026) İğde, Suat
İklim değişikliğinin tetiklediği ekstrem yağış olayları ile bu yağışların neden olduğuakımların öngörülebilmesi, sosyo-ekonomik yaşamın sürdürülebilirliği açısından büyük önemtaşımaktadır. Bu çalışmada, iklim değişikliğinin Ağrı ilindeki aşırı yağış ve akım özellikleriüzerindeki etkileri, SSP2-4.5 ve SSP5-8.5 emisyon senaryolarını içeren iki farklı paylaşımlısosyo-ekonomik rota (SSP) kapsamında değerlendirilmiştir. Analizlerde, Birleştirilmiş ModelKarşılaştırma Projesi’nin altıncı fazından (CMIP6) elde edilen 10 farklı Küresel SirkülasyonModeli (GCM) kullanılmıştır. Çalışmada, 1950-2014 dönemi CMIP6 tarihsel deney verilerreferans alınmış, 2025-2099 dönemi için geleceğe yönelik projeksiyonlar incelenmiştir. Hemtarihsel hem de geleceğe yönelik GCM çıktıları, Ağrı meteoroloji istasyonu verileriyle dağılımeşleştirmesi yöntemi uygulanarak yanlılık düzeltmesine tabi tutulmuştur. Mevsimsel ve yıllıkyağış ortalamalarındaki değişimler, tarihsel referans dönemi (1950-2014) ile kısa (2025-2049),orta (2050-2074) ve uzun vadeli (2075-2099) gelecek dönemler için 25’er yıllık periyotlarhâlinde analiz edilmiştir. Günlük maksimum yağış serileri kullanılarak 5, 10, 25, 50, 100, 200ve 500 yıllık tekerrürlü yağış miktarları log-normal (iki parametreli), log-normal (üçparametreli), log-Pearson tip III ve Gumbel olasılık dağılım fonksiyonları ile hesaplanmıştır.Tekerrür periyotlarına ilişkin elde edilen medyan değerler, SSP2-4.5 ve SSP5-8.5 senaryolarıaltındaki değişimlerin belirlenmesinde referans olarak kullanılmıştır. Elde edilen sonuçlaragöre, SSP2-4.5 senaryosu altında tekerrürlü yağış miktarlarında %16.9-%24.8; SSP5-8.5senaryosu altında ise %19.7-%34.3 aralığında artış beklenmektedir. Yağışlardan türetilenakımlar Snyder yöntemi ile hesaplanmış olup, SSP2-4.5 senaryosunda %38.0-%52.0; SSP5-8.5senaryosunda ise %52.3-%72.3 arasında artışlar öngörülmektedir. Mevsimseldeğerlendirmeler, sonbahar ve yaz aylarında yağışlarda azalma, kış ve ilkbahar aylarında iseartış eğilimi olacağını göstermektedir. Bu çalışma, su ile ilgili altyapı projelerini planlarkendeğişen iklim koşullarını dikkate alınmasının önemini vurgulamaktadır.
