Kırşehir Ahi Evran Üniversitesi Kurumsal Akademik Arşivi
DSpace@Kırşehir, Kırşehir Ahi Evran Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve yayınların etkisimi artırmak için telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Cardioprotective Effects of Carvacrol in the İsoproterenol-İnduced Myocardial İnfarction Model
(BioMed Central Ltd, 2025) Koçak, Seda; Kalkan, Kübra Tuğçe; Öztürk, Kübra; Aydın, Ömürcan Sadettin
Objective: Cardiovascular diseases are significant health problems that cause high mortality rates worldwide. Myocardial infarction (MI), in particular, is one of the leading conditions among these diseases. The aim of this study is to evaluate the potential therapeutic approach of carvacrol in the treatment of cardiovascular diseases by investigating its protective effects against myocardial infarction through oxidative stress and biomarker levels. Materials and methods: In this study, 28 male Wistar albino rats were used, and divided into 4 groups: Control, Carvacrol, Myocardial Infarction (MI), and MI + Carvacrol. Carvacrol was administered at a dose of 50 mg/kg for six weeks. The induction of MI was performed during the last 2 days of carvacrol administration by administering 100 mg/kg isoproterenol subcutaneously. At the end of the experiment, blood pressure, biomarkers such as troponin T, BNP, GDF-15, and IL-6 were measured, and cardiac tissue was histopathologically examined. Results: The results show that in the MI group, troponin T, BNP, IL-6 and GDF-15 levels were increased, while diastolic blood pressure and heart rate were decreased. In the carvacrol-treated group, troponin T, BNP, IL-6 and GDF-15 levels were decreased. Carvacrol did not significantly affect systolic, diastolic, mean arterial pressure, or heart rate in experimental groups. Moreover, carvacrol decreased necrosis, edema, and mononuclear cell infiltration in the heart tissue, which were increased due to MI. Conclusion: In conclusion, carvacrol demonstrated protective effects against myocardial infarction. Carvacrol alleviated histopathological damage by reducing inflammatory biomarkers. In addition to carvacrol improved troponin T and BNP markers.These findings suggest that carvacrol may be a promising agent in the treatment of cardiovascular diseases. However, more comprehensive and long-term studies are needed to confirm this effect and transfer it to clinical applications.
Biomedical Ethical Analysis of Patients’ Perspectives on Posthumous Reproduction in A Gynecology and Obstetrics Clinic
(BioMed Central Ltd, 2025) Köken, Arif Hüdai; Kara, Özlem; İnce, Nebahat; Kara, Mustafa
Background: This study explores the perspectives of patients attending a gynecology and obstetrics clinic in Türkiye regarding posthumous reproduction from a biomedical ethics standpoint. To examine the bioethical issues about the subject related surviving spouses and potential children may face. Methods: A cross-sectional and descriptive survey was conducted between May 1, 2023, and August 1, 2023. A total of 200 women visiting the Kırşehir Ahi Evran University Gynecology and Obstetrics Clinic participated in face-to-face interviews. The survey comprised 20 questions aimed at evaluating participants' views on posthumous reproduction. Data were analyzed using SPSS 25 software, and the Chi-square test was applied, with statistical significance set at p < 0.05. Results: Of the participants, 59.5% opposed a woman having a child using a preserved embryo after her husband’s death, while 75.5% disapproved of a man having a child through a surrogate after his wife's death. Additionally, 55% supported a woman's reproductive rights in such cases, whereas 57% objected to a man exercising the same right. Concerns about the potential negative impact on children ranged from 50% to 57.5%. The majority believed that posthumous reproduction should only be ethically permissible if the deceased had provided explicit consent beforehand. Conclusion: Findings indicate that perspectives on posthumous reproduction are influenced by social, cultural, and ethical considerations. Turkish society generally maintains a reserved and critical stance on this issue, with stronger opposition to male surrogacy. The ethical and legal implications of posthumous reproduction highlight the need for legal regulations and public awareness initiatives.
Do Shocks to Tourism Receipts Have A Transitory or Persistent Nature? A Comparison of Traditional and Artificial İntelligence-Based Analytical Procedures
(SAGE Publications Inc., 2026) Koçak, Emrah; Bulut, Ümit; Bakır, Selim
The goal of this study is to determine whether the effects of shocks to tourism receipts and GDP are transitory or permanent in 10 major tourism destinations (Australia, Germany, Italy, Japan, Mexico, Poland, Portugal, South Korea, Switzerland, and the US) using data from 1995 to 2022. The study initially employs unit root tests that employ a variety of methods for modeling structural breaks, then performs a unit root test that is based on artificial intelligence. According to the results of the artificial intelligence-based unit root test, the effects of shocks to tourism receipts are transitory in Italy, Japan, and Mexico, while the effects of shocks to GDP are temporary in Australia, Poland, and Switzerland. The study provides policy recommendations for the tourism and hospitality sector and GDP in countries where the impacts of shocks are enduring.
Effects of Liraglutide on the Testis of Rats with Experimental Diabetes and İschemia-Reperfusion İnjury
(Taylor and Francis Ltd., 2025) Hazır, Sinem; Çoşkun, Gülfidan; Sencar, Leman; Tuli, Abdullah; Dağlıoğlu, Yusuf Kenan
Our study aimed to investigate the antidiabetic, antioxidative, and antiapoptotic effects of liraglutide on the testes of rats with diabetes and ischemia/reperfusion injury. Subjects were divided into three groups: control, diabetes, and torsion groups. Rats with diabetes were further divided into two subgroups such as diabetes and diabetes+Liraglutide groups. The torsion group was divided into three subgroups such as torsion, torsion/detorsion, and torsion/detorsion+Liraglutide groups. Malondialdehyde (MDA), superoxide dismutase (SOD), and testosterone levels were measured from blood samples. Also, testicular tissue samples were examined by light and electron microscopy. Apoptosis was assessed using immunohistochemistry for caspase-3. Degeneration of seminiferous tubules and interstitium was observed in the diabetes, torsion, and torsion/detorsion groups, while Liraglutide treated groups showed normal seminiferous tubules morphology. Elevated levels of apoptosis, i.e. caspase-3, were observed in diabetes, torsion, and torsion/detorsion groups (P < 0.05), whereas Liraglutide treated groups had similar levels of apoptosis as the control group. MDA levels of diabetes, torsion, and torsion/detorsion groups were increased (P < 0.05), while SOD and testosterone levels were decreased (P < 0.05). However, Liraglutide treated groups, SOD, MDA, and testosterone levels were found similar to the control group. In conclusion, Liraglutide positively affects structural changes and hormone levels in diabetes and torsion/detorsion groups.
Geomechanical Behaviour of Clay Stabilised with Low-Calcium Fly Ash and Alkali Activation
(Springer, 2026) Turan, Canan; Javadi, Akbar A; Vinai, Raffaele; Öz, İbrahim
This study examines the geomechanical behaviour of clay stabilised with alkali-activated fly ash and non-activated fly ash to improve the geotechnical properties of clay soils. Class F fly ash and its alkali-activated form were employed as stabilisers to provide a sustainable alternative to traditional binders like cement and lime. Laboratory experiments, including one-dimensional consolidation and consolidated-undrained triaxial tests, were conducted on clay samples treated with varying fly ash contents and curing durations. The results indicated that alkali-activated fly ash significantly improved the mechanical performance of clay by reducing compressibility, swelling, and permeability during curing. Triaxial test results showed that alkali activation increased strength parameters and altered the stress–strain behaviour of the soil from ductile to brittle. Specifically, clay treated with 25% alkali-activated fly ash and cured for 28 days achieved nearly a ninefold increase in maximum deviator stress compared to untreated samples. Both fly ash types improved shear strength and critical state parameters, though non-activated fly ash resulted in lower effective cohesion than the control. Overall, the findings demonstrate that untreated Class F fly ash has limited binding capacity, while alkali activation substantially enhances the stabilisation effect, offering a promising and sustainable alternative for geotechnical soil improvement.
