Kırşehir Ahi Evran Üniversitesi Kurumsal Akademik Arşivi
DSpace@Kırşehir, Kırşehir Ahi Evran Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve yayınların etkisimi artırmak için telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
The Bioarchaeological Analysis of a New Early Bronze Age Settlement in Central Anatolia: Harhar Deresi (3000-2700 BC)
(Universidad de la Frontera, 2025) Erkman, Ahmet Cem; Şener, Elçin; Taş, Ali; Özbey, Serpil Özdemir; Shirvan, Samad Joshani
Konya Province, one of the most significant Bronze Age settlements in Anatolia, is notable for its unique mounds. Harhar Deresi, located in one of the distinctive plateaus of Central Anatolia, is a pastoral settlement that was overlooked during surface surveys conducted by many researchers due to the region's topographic features. This settlement was first discovered by chance in 2018 during the construction of the Ankara-Nigde Highway and its connecting roads, and a rescue excavation was carried out in part of the site. This study presents paleopathological findings that contribute to an understanding of daily life in a recently discovered settlement from the Early Bronze II period (3000-2700 BC). The research is guided by two primary objectives. Firstly, it seeks to provide a qualitative paleopathological assessment of diseases, informed by observations related to osteoarthritis, trauma, osteoid osteoma, enthesopathy, and supracondylar process syndrome. Efforts have been made to ensure that this study is quantitative by comparing the pathology rates with those of contemporary ancient Anatolian societies. Secondly, the study aimed to understand the general nutrition, health, and socio-economic structure of this society, as revealed by dental anthropological findings. Our research indicates that the population engaged in intensive agricultural activities and followed a low-protein diet, likely due to the demands of strenuous physical labor. Furthermore, this study endeavors to introduce the physiological stress and health conditions experienced by the newly discovered Early Bronze Age population, serendipitously located in the Central Anatolia region, into the academic literature through a bioarchaeological perspective.
Optical, Non-Linear Optical and Electronic Properties of 1,3,4-Oxadiazole Derivative: A Combined Experimental and Theoretical Study
(Springer, 2025) Şaş, Emine Babur
We investigated the electronic and optical properties of an organic material, 2-(4-bromophenyl)-5-phenyl-1,3,4-oxadiazole (BP-OXA), combining experimental measurements and theoretical calculations. FT-IR and FT-Raman spectra were recorded in the solid phase. The NMR chemical shifts (1H and 13C) were recorded in chloroform solution. The 1H and 13C NMR spectra were computed by using the gauge-invariant atomic orbital (GIAO) method, showing good agreement with the experimental ones. PL studies were utilized to investigate the light-emitting properties of BP-OXA. UV–Vis spectra were recorded in dichloromethane (DCM) at different concentrations, showing strong absorption peaks in the near-UV region (200–400 nm). In the study, we calculated the HOMO–LUMO energy gaps, UV spectra, and optical parameters of the molecule using B3LYP and CAM-B3LYP functional methods and evaluated their compatibility with experimental data. The experimental optical band gap (Eg) of the molecule of approximately 3.84 eV indicates that it has semiconductor properties. Additionally, refractive index values (1.70–2.58) and optical conductivity parameters indicate that BP-OXA is well-suited for optoelectronic applications. The material exhibits robust optical behavior, supported by high dipole moments and significant hyperpolarizability values (5503.52 × 10⁻33 esu), suggesting potential for advanced photonic technologies. These results highlight BP-OXA as a promising candidate for applications in optoelectronic devices and nonlinear optics.
Effects of 3-Bromo-2-Oxopropionic Acid and Licl Treatment Combined with Electroporation on Apoptotic and Metabolic Responses in DLD-1 Colon Cancer Cells
(Springer, 2025) Gürsoy, Güney; Çiçek, Zehra
Colon cancer is particularly increasing in incidence in developed countries, and it ranks first in terms of morbidity and mortality worldwide. As in other types of cancer, metabolic changes and cellular death mechanisms play a critical role in cancer treatment. Cancer cells prefer glycolysis for energy production even in the presence of oxygen; this phenomenon is known as the Warburg effect. Glycolysis, which is essentially an anaerobic process, provides metabolic adaptation by preventing mitochondrial oxidative phosphorylation in cancer cells. Electroporation (EP) is a method that increases the uptake of drugs into the cell by creating temporary pores in the cell membrane. 3-Bromo-2-oxopropionic acid and Lithium chloride (LiCl) are agents that may show anticancer potential through different mechanisms. The aim of this study was to investigate the potential anticancer effects of the EP-assisted combination of 3-Bromo-2-oxopropionic acid and LiCl agents in DLD-1 colon cancer cells and to evaluate how these effects occur at the level of cell viability, apoptotic activity and metabolic markers. In the study, cell viability was evaluated by WST-8 tetrazolium based colorimetric method. Within the scope of analysis of apoptotic activity and metabolic responses; caspase-3, Phosphatidylinositol 3-kinase (PI3K) and Glucose transporter-1 (GLUT-1) levels were determined by ELISA method. While no change in cell viability was observed at 10 and 20 µM doses of 3-Bromo-2-oxopropionic acid, a significant decrease was detected in its combination with EP. IC50 value was determined as 37.99 ± 2.34 µM in a single application and as 27.33 ± 1.99 µM in its combination with EP. While low doses of LiCl (5 and 10 mM) did not affect cell viability, a significant decrease was detected at doses of 50, 75 and 100 mM. In its combination with EP, a significant loss of viability was observed even at low doses and the IC50 value decreased from 98.92 ± 0.64 mM to 81.88 ± 1.64 mM. A decrease in IC50 doses is observed in the treatment with the combination of both 3-Bromo-2-oxopropionic acid and LiCl with EP. The combined treatment enables the same lethal effect on cancer cells with lower drug doses. Caspase-3 activity increased significantly in combined applications with EP. While 3-Bromo-2-oxopropionic acid alone did not change the level of PI3K, it caused a significant increase in its combination with EP. While LiCl caused an increase in the level of PI3K at low doses, a decrease was detected in its combination with EP. Regular partial increases in GLUT-1 level were determined in a dose-dependent manner in 3-Bromo-2-oxopropionic acid treatment alone. A similar increase was determined at 20 and 30 µM doses combined with EP, while a decrease occurred at 40 µM. While no significant increase was detected in GLUT-1 levels compared to the control group in 10 mM LiCl treatment alone and in combination with EP, a significant increase was detected in 50 and 75 mM LiCl doses compared to the control group. In conclusion, 3-Bromo-2-oxopropionic acid and LiCl show anticancer potential by affecting apoptotic and metabolic processes, and their combination with EP increases these effects. In order to explain the effectiveness of these treatment approaches from every perspective, it is recommended to conduct in vitro studies on different colon cancer cell lines and evaluate them with more comprehensive in vivo and clinical studies.
Cardioprotective Effects of Carvacrol in the İsoproterenol-İnduced Myocardial İnfarction Model
(BioMed Central Ltd, 2025) Koçak, Seda; Kalkan, Kübra Tuğçe; Öztürk, Kübra; Aydın, Ömürcan Sadettin
Objective: Cardiovascular diseases are significant health problems that cause high mortality rates worldwide. Myocardial infarction (MI), in particular, is one of the leading conditions among these diseases. The aim of this study is to evaluate the potential therapeutic approach of carvacrol in the treatment of cardiovascular diseases by investigating its protective effects against myocardial infarction through oxidative stress and biomarker levels. Materials and methods: In this study, 28 male Wistar albino rats were used, and divided into 4 groups: Control, Carvacrol, Myocardial Infarction (MI), and MI + Carvacrol. Carvacrol was administered at a dose of 50 mg/kg for six weeks. The induction of MI was performed during the last 2 days of carvacrol administration by administering 100 mg/kg isoproterenol subcutaneously. At the end of the experiment, blood pressure, biomarkers such as troponin T, BNP, GDF-15, and IL-6 were measured, and cardiac tissue was histopathologically examined. Results: The results show that in the MI group, troponin T, BNP, IL-6 and GDF-15 levels were increased, while diastolic blood pressure and heart rate were decreased. In the carvacrol-treated group, troponin T, BNP, IL-6 and GDF-15 levels were decreased. Carvacrol did not significantly affect systolic, diastolic, mean arterial pressure, or heart rate in experimental groups. Moreover, carvacrol decreased necrosis, edema, and mononuclear cell infiltration in the heart tissue, which were increased due to MI. Conclusion: In conclusion, carvacrol demonstrated protective effects against myocardial infarction. Carvacrol alleviated histopathological damage by reducing inflammatory biomarkers. In addition to carvacrol improved troponin T and BNP markers.These findings suggest that carvacrol may be a promising agent in the treatment of cardiovascular diseases. However, more comprehensive and long-term studies are needed to confirm this effect and transfer it to clinical applications.
Biomedical Ethical Analysis of Patients’ Perspectives on Posthumous Reproduction in A Gynecology and Obstetrics Clinic
(BioMed Central Ltd, 2025) Köken, Arif Hüdai; Kara, Özlem; İnce, Nebahat; Kara, Mustafa
Background: This study explores the perspectives of patients attending a gynecology and obstetrics clinic in Türkiye regarding posthumous reproduction from a biomedical ethics standpoint. To examine the bioethical issues about the subject related surviving spouses and potential children may face. Methods: A cross-sectional and descriptive survey was conducted between May 1, 2023, and August 1, 2023. A total of 200 women visiting the Kırşehir Ahi Evran University Gynecology and Obstetrics Clinic participated in face-to-face interviews. The survey comprised 20 questions aimed at evaluating participants' views on posthumous reproduction. Data were analyzed using SPSS 25 software, and the Chi-square test was applied, with statistical significance set at p < 0.05. Results: Of the participants, 59.5% opposed a woman having a child using a preserved embryo after her husband’s death, while 75.5% disapproved of a man having a child through a surrogate after his wife's death. Additionally, 55% supported a woman's reproductive rights in such cases, whereas 57% objected to a man exercising the same right. Concerns about the potential negative impact on children ranged from 50% to 57.5%. The majority believed that posthumous reproduction should only be ethically permissible if the deceased had provided explicit consent beforehand. Conclusion: Findings indicate that perspectives on posthumous reproduction are influenced by social, cultural, and ethical considerations. Turkish society generally maintains a reserved and critical stance on this issue, with stronger opposition to male surrogacy. The ethical and legal implications of posthumous reproduction highlight the need for legal regulations and public awareness initiatives.
