Kırşehir Ahi Evran Üniversitesi Kurumsal Akademik Arşivi
DSpace@Kırşehir, Kırşehir Ahi Evran Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve yayınların etkisimi artırmak için telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Evaluation of Thiol/Disulfide Homeostasis and İschemia‑modified Albumin Levels in Symptomatic Dermographism
(Wolters Kluwer Medknow Publications, 2025) Metin, Mahmut Sami; Tehçi, Tuğba; Kolukırık, İlkay; Akoğul, Serkan; Öner, Ümran; Metin, Zuhal
Background: Symptomatic dermographism (SD) is the most common chronic inducible urticaria (CIndU) type. Thiol/disulfide homeostasis (TDH) and ischemia‑modified albumin (IMA) levels are indicators of oxidative stress. Aim: Our study aims to investigate the role of thiol/disulfide balance and IMA levels in the pathogenesis of SD. This focus guides our research and helps us to better understand the disease. Materials and Methods: This cross‑sectional study, conducted with utmost care and precision, included 50 SD patients and 50 healthy volunteers. The patients and controls were meticulously evaluated regarding IMA, native thiol, total thiol, and disulfide levels and disulfide/native thiol, disulfide/total thiol, and native thiol/total thiol ratios, ensuring a thorough and reliable understanding of the data. Results: In our study, the patient group demonstrated significantly higher levels of native thiol, total thiol, disulfide, and IMA values than the control group (P < 0.05). Conclusions: In patients with SD, impaired TDH and increased IMA suggest that oxidative stress may play a significant role in the disease pathogenesis, underscoring the importance of our findings.
Using as Screw of PEEK in Femur Neck Fractures as an Alternative Biomaterial
(Springer, 2025) Kurt, Cengizhan; Gök, Arif; İnal, Sermet; Urtekin, Levent; Gök, Kadir
Titanium screws used in femoral neck fracture fixation may lead to issues such as stress shielding and localized stress concentration. This study investigates the feasibility of using polyether-ether-ketone (PEEK) screws arranged in a triangular configuration as a potential alternative. Mechanical performance, biocompatibility, and load-bearing capacity are significant for these applications. Finite element analysis (FEA) revealed that PEEK screws exhibited a lower insertional stress of 92.26 MPa but experienced higher fracture line stress (79.96 MPa), gap (0.50 mm), and penetration (0.0074 mm), indicating increased micromotion. The calculated safety factor was 1.0297, which is adequate for average patients but may not ensure safety under high-load conditions. Compared to titanium, PEEK offered improved stress distribution and fatigue resistance but also demonstrated mechanical limitations. Overall, PEEK screws show promise as a bioinert and radiolucent alternative in orthopaedic applications, yet further optimization is needed for broader clinical adoption in high-demand scenarios.
The Scottish İnflammatory Prognostic Score: A Novel Biomarker for Predicting İn-Hospital Mortality in Acute Heart Failure with Reduced Ejection Fraction
(Elsevier Inc., 2025) Taş, Alperen; Tunca, Çağatay; Tanık, Veysel Ozan; Özlek, Bülent
Background: Acute heart failure with reduced ejection fraction (AHF) remains a leading cause of ED visits, hospitalizations, and in-hospital mortality. Objectives: To evaluate the prognostic utility of the Scottish Inflammatory Prognostic Score (SIPS) in patients with AHF. Methods: This retrospective study analyzed 508 patients admitted with AHF between November 2022 and November 2024. The SIPS was calculated based on albumin and neutrophil levels. Clinical and laboratory parameters were compared between survivors and non-survivors to identify predictors of all-cause in-hospital mortality. Results: At a median follow-up of 10 days (range 4–28), 63 patients (12.4 %) died. The mean age of the study population was 63 years, with non-survivors being older on average. Multivariable Cox proportional regression analysis revealed high SIPS values (HR: 2.335, 95 % CI: 1.044 - 5.221, p = 0.039), advanced age, elevated NT-pro-BNP levels, chronic renal failure, and low serum sodium as independent predictors of in-hospital mortality. When patients were categorized by SIPS scores of 0, 1, and 2, the associated mortality rates were 5.1 %, 14.0 %, and 46.0 %, respectively (p < 0.001). Additionally, ROC curve analysis indicated that a SIPS threshold of 0.5 effectively predicted in-hospital mortality, demonstrating a sensitivity of 77 % and a specificity of 58 % (95 % CI: 0.661–0.803, p < 0.001). Conclusions: This study is the first to analyze the association between SIPS and in-hospital mortality in patients with AHF. Integrating SIPS with other established risk factors may help improve the identification of high-risk AHF patients who could benefit from closer monitoring and intensified therapy, though further validation is warranted.
Some Novel Optical Pulses in Hydrodynamical Nonlinear Complex Equation using M-Truncated Fractional Derivative
(Nature Research, 2025) İlhan, Esin; Rehman, Shafqat Ur; Bilal, Muhammad; Baskonuş, Hacı Mehmet; Alawaideh, Yazen M.
This study investigates soliton solutions and dynamic wave structures in the complex Ginzburg-Landau (CGL) equation, which is crucial for understanding wave propagation in various physical systems. We employ three analytical methods: the Kumar-Malik method, the generalized Arnous method, and the energy balance method to derive novel closed-form solutions. These solutions exhibit diverse solitonic phenomena, including multi-wave solitons, complex solitons, singular solitons, periodic oscillating waves, dark-wave, and bright-wave profiles. Our results reveal new families of exact solitary waves via the generalized Arnous method and diverse soliton solutions through the Kumar-Malik method, including hyperbolic, trigonometric, and Jacobi elliptic functions. Verification is ensured through back-substitution to the considered model using Mathematica software. Additionally, we plot the various graphs with the appropriate parametric values under the influence of the M-truncated fractional derivative to visualize the solution behaviors with varying parameter values. This research contributes significantly to understanding wave dynamics in physical oceanography, and the unique outcomes explored in this research will play a vital role for the forthcoming investigation of nonlinear equations.
Determination of Quality Levels of Fish Oils Recovered from Trout Waste using Machine Learning and Odor Sensors
(Springer, 2025) Yavuzer, Emre; Yaprak Uslu, Dilek; Köse, Memduh; Yetişen, Mehmet; Alaşalvar, Hamza
[Not Abstract Available]
