Relationship Between Mean Platelet Volume and Pulmonary Embolism in Patients With Deep Vein Thrombosis
Uysal, Bayram Ali
Alpay, Mehmet Fatih
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Background Mean platelet volume (MPV) has been demonstrated to be associated with deep vein thrombosis (DVT). However, its role in the prediction of pulmonary embolism (PE), which is a major complication of DVT, is still unclear. Therefore, we investigated the association of MPV values with acute PE in patients with DVT. Method The study included three groups: patients with DVT and PE (n = 98); patients with DVT without PE (n = 97); and control group (No DVT, No PE, n = 98). We also evaluated DVT patients according to the MPV values on admission and categorised them into two groups: MPV <= 9.15 fL (n = 82) and MPV > 9.15 fL (n = 113). Results MPV was significantly higher in all DVT patients than controls (9.3 +/- 0.9 fL vs 7.9 +/- 0.7 fL, p < 0.001) and in DVT patients with PE than DVT patients without PE (9.9 +/- 0.6 fL vs 8.7 +/- 0.7 fL, p < 0.001). The rate of PE was higher in patients with DVT with MPV > 9.15 fL than those with MVP <= 9.15 fL (75.2% vs 15.9%, p < 0.001). The presence of PE in patients with DVT was independently associated with MPV (OR: 22.19, 95% CI: 9.39-53.19, P < 0.001). Conclusion Although our findings should be considered within the limitations of the study, they suggest that MPV measures may be elevated in DVT patients and a higher MPV may be associated with PE in patients with DVT.