Yazar "Özkan-Kotiloğlu, Selin" için listeleme
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Are BPA-free plastics safe for aquatic life? - Fluorene-9-bisphenol induced thyroid-disrupting effects and histopathological alterations in adult zebrafish (Danio rerio)
Özkan-Kotiloğlu, Selin; Arslan, Pınar; Akça, Gülçin; Günal, Aysel Çağlan (Elsevier Inc., 2022)Fluorene-9-bisphenol (BPFL) is used as an alternative compound for bisphenol A, an endocrine disruptor compound which is present in various materials including plastic bottles and packaging. Although it is used extensively ... -
Are BPA-free plastics safe for aquatic life?-Fluorene-9-bisphenol induced thyroid-disrupting effects and histopathological alterations in adult zebrafish (Danio rerio)
Özkan-Kotiloğlu, Selin; Arslan, Pınar; Akça, Gülçin; Günal, Aysel Çağlan (Elsevier Scıence Inc, 2022)Fluorene-9-bisphenol (BPFL) is used as an alternative compound for bisphenol A, an endocrine disruptor compound which is present in various materials including plastic bottles and packaging. Although it is used extensively ... -
Effect of PDYN rs2281285, rs2235749 and rs910080 gene polymorphisms on the intensity of depression symptoms and negative craving in heroin addicts
Kaya-Akyüzlü, Dilek; Özkan-Kotiloğlu, Selin; Yalçın-Şahiner, Şafak; Ayaz, Nagihan (Institut za Bioloska Istrazivanja, 2021)The present study was undertaken to explore whether prodynorphin (PDYN) polymorphisms have an effect on the intensity of depressive symptoms and negative craving in heroin addicts in a sample of 100 heroin addicts and 108 ... -
Effects of UGT2B7 rs7662029 and rs7439366 polymorphisms on sublingual buprenorphine metabolism in heroin addicts: An improved PCR-RFLP assay for the detection of rs7662029 polymorphism
Kaya-Akyüzlü, Dilek; Özkan-Kotiloğlu, Selin; Bal, Ceylan; Yalçın -Şahiner, Şafak; Avcıoğlu, Gamze; Danışman, Mustafa (Elsevier, 2022)This study aimed to determine the effects of UGT2B7 rs7662029 and rs7439366 polymorphisms on plasma buprenorphine (BUP) concentration and different treatment responses in a sample of 109 patients with opioid use disorder ... -
The involvement of miRNAs in CYP450 gene expression: A brief review of the literature
Tezcan, Tuğba; Özkan-Kotiloğlu, Selin; Kaya-Akyüzlü, Dilek (Marmara University, 2022)Drug biotransformation is a critical process in metabolic elimination of drugs. It occurs mainly in the liver as well as in other tissues such as kidney and small intestine and consists of three stages: Phase I, Phase II ... -
OPRD1 rs569356 polymorphism has an effect on plasma norbuprenorphine levels and dose/kg-normalized norbuprenorphine values in individuals with opioid use disorder
Kaya-Akyüzlü, Dilek; Özkan-Kotiloğlu, Selin; Danışman, Mustafa; Bal, Ceylan; Oğur, Begüm; İspir, Gamze Zengin (Elsevier B.V., 2023)This study aimed to determine the effects of nine OPRM1, OPRD1 and OPRK1 polymorphisms on plasma BUP and norbuprenorphine (norBUP) concentrations and various treatment responses in a sample of 122 patients receiving ... -
Sublingual buprenorphine/naloxone treatment is not affected by OPRM1 A118G and BDNF Va66Met polymorphisms, but alters the plasma beta-endorphin and BDNF levels in individuals with opioid use disorder
Kaya-Akyüzlü, Dilek; Özkan-Kotiloğlu, Selin; Bal, Ceylan; Avcıoğlu, Gamze; Şahiner, Şafak Yalçın; Şahiner, İsmail Volkan (Elsevier B.V., 2022)The study aimed to examine the genetic contribution to buprenorphine (BUP) treatment in individuals with opioid use disorder (OUD), with a specific focus on BDNF and OPRM1 genes. A total of 113 controls and 111 OUD patients ...
