Yazar "Alim, Zuhal" için listeleme
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1H-indazole molecules reduced the activity of human erythrocytes carbonic anhydrase I and II isoenzymes
Alim, Zuhal (WILEY, 2018)Carbonic anhydrase (CA) is an important metabolic enzyme family closely related to many physiological and pathological processes. Currently, carbonic anhydrase inhibitors are the target molecules in the treatment and ... -
Assessment of the inhibitory effects and molecular docking of some sulfonamides on human serum paraoxonase 1
Alim, Zuhal; Kilic, Deryanur; Koksal, Zeynep; Beydemir, Sukru; Ozdemir, Hasan (WILEY, 2017)Paraoxonase-1 (PON1) is an organophosphate hydrolyzer and antiatherogenic enzyme. Due to the PON1's crucial functions, inhibitors and activators of PON1 must be known for pharmacological applications. In this study, we ... -
Inhibition behaviours of some phenolic acids on rat kidney aldose reductase enzyme: an in vitro study
Alim, Zuhal; Kilinc, Namik; Sengul, Bulent; Beydemir, Sukru (TAYLOR & FRANCIS LTD, 2017)Aldose reductase (AR) inhibitors have vital importance in the treatment and prevention of diabetic complications. In this study, rat kidney AR was purified 19.34-fold with a yield of 3.49% and a specific activity of 0.88 ... -
Investigation of the effects of some sulfonamides on acetylcholinesterase and carbonic anhydrase enzymes
Koksal, Zeynep; Alim, Zuhal; Bayrak, Songul; Gulcin, Ilhami; Ozdemir, Hasan (WILEY, 2019)Human carbonic anhydrase I and II isoenzymes (hCA I and II) and acetylcholinesterase (AChE) are important metabolic enzymes that are closely associated with various physiological and pathological processes. In this study, ... -
Mechanism of capsaicin inhibition of aldose reductase activity
Alim, Zuhal; Kilinc, Namik; Sengul, Bulent; Beydemir, Sukru (WILEY, 2017)Aldose reductase (AR) inhibitors play a vital importance as a potential therapeutic and preventive medicine when it comes to hyperglycemia associated diabetic complications. Additionally, capsaicin is used as a food additive ... -
Potent Inhibitory Effects of Some Phenolic Acids on Lactoperoxidase
Koksal, Zeynep; Alim, Zuhal; Beydemir, Sukru; Ozdemir, Hasan (WILEY-BLACKWELL, 2016)Lactoperoxidase (LPO) plays a key role in immune response against pathogens. In this study, we examined the effects of some phenolic acids on LPO. For this purpose, bovine milk LPO was purified 380.85-fold with a specific ... -
Some Anticancer Agents Act on Human Serum Paraoxonase-1 to Reduce Its Activity
Alim, Zuhal; Beydemir, Sukru (WILEY-BLACKWELL, 2016)Human serum paraoxonase (hPON1) is an important antioxidant enzyme. It protects low-density lipoproteins against oxidative stress and prevents atherosclerosis development. Anticancer agents have cardiotoxic effects, and ... -
Some characteristics of new and innovative COX inhibitor derivatives: Potent hCA-I and hCA-II inhibitors supported by molecular docking studies
Karakılıç, Emel; Alim, Zuhal; Emirik, Mustafa; Baran, Arif (Wiley, 2022)In this study, two novel metallophthalocyanines (ZnPc and CoPc) were synthesized using the corresponding metal salts 4-(4-(4-[4-chlorophenyl]-5-methylisoxazol-3-yl)phenoxy)-phthalonitrile (11), prepared from the reaction ... -
Some indazoles reduced the activity of human serum paraoxonase 1, an antioxidant enzyme: in vitro inhibition and molecular modeling studies
Alim, Zuhal; Kilic, Deryanur; Demir, Yeliz (TAYLOR & FRANCIS LTD, 2019)Background: Paraoxonase 1 (PON1: EC 3.1.8.1) is a vital antioxidant enzyme against mainly atherosclerosis and many other diseases associated with oxidative stress. Thus, studies related to PON1 have an important place in ... -
The synthesis of novel pyrazole-3,4-dicarboxamidesbearing 5-amino-1,3,4-thiadiazole-2-sulfonamide moiety with effective inhibitory activity against the isoforms of human cytosolic carbonic anhydrase I and II
Mert, Samet; Alim, Zuhal; Isgor, Mehmet Mustafa; Beydemir, Sukru; Kasimogullari, Rahmi (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2016)A series of 1-(3-substituted-phenyl)-5-phenyl-N-3,N-4-bis(5-sulfamoyl-1,3,4-thiadiazol-2-yl)-1H-pyrazole-3,4- dicarboxamides (4-15) were synthesized. The structures of these pyrazole-sulfonamides were confirmed by FT-IR, ...
