Yazar "Beydemir, Sukru" için listeleme
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Assessment of the inhibitory effects and molecular docking of some sulfonamides on human serum paraoxonase 1
Alim, Zuhal; Kilic, Deryanur; Koksal, Zeynep; Beydemir, Sukru; Ozdemir, Hasan (WILEY, 2017)Paraoxonase-1 (PON1) is an organophosphate hydrolyzer and antiatherogenic enzyme. Due to the PON1's crucial functions, inhibitors and activators of PON1 must be known for pharmacological applications. In this study, we ... -
Inhibition behaviours of some phenolic acids on rat kidney aldose reductase enzyme: an in vitro study
Alim, Zuhal; Kilinc, Namik; Sengul, Bulent; Beydemir, Sukru (TAYLOR & FRANCIS LTD, 2017)Aldose reductase (AR) inhibitors have vital importance in the treatment and prevention of diabetic complications. In this study, rat kidney AR was purified 19.34-fold with a yield of 3.49% and a specific activity of 0.88 ... -
Mechanism of capsaicin inhibition of aldose reductase activity
Alim, Zuhal; Kilinc, Namik; Sengul, Bulent; Beydemir, Sukru (WILEY, 2017)Aldose reductase (AR) inhibitors play a vital importance as a potential therapeutic and preventive medicine when it comes to hyperglycemia associated diabetic complications. Additionally, capsaicin is used as a food additive ... -
Potent Inhibitory Effects of Some Phenolic Acids on Lactoperoxidase
Koksal, Zeynep; Alim, Zuhal; Beydemir, Sukru; Ozdemir, Hasan (WILEY-BLACKWELL, 2016)Lactoperoxidase (LPO) plays a key role in immune response against pathogens. In this study, we examined the effects of some phenolic acids on LPO. For this purpose, bovine milk LPO was purified 380.85-fold with a specific ... -
Some Anticancer Agents Act on Human Serum Paraoxonase-1 to Reduce Its Activity
Alim, Zuhal; Beydemir, Sukru (WILEY-BLACKWELL, 2016)Human serum paraoxonase (hPON1) is an important antioxidant enzyme. It protects low-density lipoproteins against oxidative stress and prevents atherosclerosis development. Anticancer agents have cardiotoxic effects, and ... -
The synthesis of novel pyrazole-3,4-dicarboxamidesbearing 5-amino-1,3,4-thiadiazole-2-sulfonamide moiety with effective inhibitory activity against the isoforms of human cytosolic carbonic anhydrase I and II
Mert, Samet; Alim, Zuhal; Isgor, Mehmet Mustafa; Beydemir, Sukru; Kasimogullari, Rahmi (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2016)A series of 1-(3-substituted-phenyl)-5-phenyl-N-3,N-4-bis(5-sulfamoyl-1,3,4-thiadiazol-2-yl)-1H-pyrazole-3,4- dicarboxamides (4-15) were synthesized. The structures of these pyrazole-sulfonamides were confirmed by FT-IR, ...
