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Intermolecular heterocyclization of alkynones with 2-mercaptoacetaldehyde under metal-free conditions: synthesis of 2,3-disubstituted thiophenes

Vatansever, Erol Can; Kilic, Kubra; Ozer, Merve Sinem; Koza, Gani; Menges, Nurettin; Balci, Metin (PERGAMON-ELSEVIER SCIENCE LTD, 2015)

A concise and regioselective approach for the synthesis of 2,3-disubstituted thiophene derivatives has been developed. The synthetic strategy relies on the reaction of an in situ generated 2-mercaptoacetaldehyde with various ...