Yazar "Tekcan, Akin" için listeleme
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Angiotensin converting enzyme and methylenetetrahydrofolate reductase gene variations in fibromyalgia syndrome
Inanir, Ahmet; Yigit, Serbulent; Tekcan, Akin; Pinarli, Ferda Alpaslan; Inanir, Sema; Karakus, Nevin (ELSEVIER, 2015)Objective: Fibromyalgia syndrome (FM) is a common disease characterized by generalized body pain, sensitivity in certain physical areas (sensitive points), lowered pain threshold, sleep disorder, and fatigue. The study ... -
Angiotensin Converting Enzyme Gene Insertion/Deletion Variant and Familial Mediterranean Fever-related Amyloidosis
Nursal, Ayse Feyda; Turkmen, Ercan; Kaya, Suheyla Uzun; Tekcan, Akin; Sezer, Ozlem; Celik, Sumeyya Deniz; Yigit, Serbulent (IRANIAN SOC NEPHROLGY, 2018)Introduction. The most important complication of familial Mediterranean fever (FMF) is secondary amyloidosis, which can lead to kidney failure. Genetic variability in the genes of various components of the renin-angiotensin ... -
Effect of a functional variant of tumor necrosis factor-beta gene in temporomandibular disorders: A pilot study
Yerliyurt, Kaan; Nursal, Ayse Feyda; Tekcan, Akin; Karakus, Nevin; Tumer, Mehmet K.; Yigit, Serbulent (WILEY, 2019)Background Temporomandibular disorders (TMD) are a group of conditions that cause chronic orofacial pain. The tumor necrosis factor beta (TNF-beta) is a proinflammatory cytokine that is involved in the various aspects of ... -
The Effect of IL-4 Gene Polymorphism in Carpal Tunnel Syndrome
Tekcan, Akin; Cevik, Betul; Inanir, Ahmet; Yigit, Serbulent (DERMAN MEDICAL PUBL, 2016)Aim: Carpal tunnel syndrome (CTS) is a neurological disorder characterized by paresthesia and pain in the hands due to lesions and /or dysfunction of the median nerve at the wrist. The exact pathogenesis of CTS is not ... -
Effects of subtelomeric copy number variations in miscarriages
Tekcan, Akin; Elbistan, Mehmet; Tural, Sengul; Cetinkaya, Mehmet Bilge (TAYLOR & FRANCIS LTD, 2015)Purpose: This study was performed on miscarriage samples for chromosome analysis to detect copy number variations (CNVs) related to subtelomeric regions, and with these results we aimed to adapt multiplex ligation-dependent ... -
Evaluation of apoptotic cell death on liver and kidney tissues following administration of levetiracetam during prenatal period
Tekcan, Akin; Tural, Sengul; Elbistan, Mehmet; Guvenc, Tolga; Ayas, Bulent; Kara, Nurten (TAYLOR & FRANCIS LTD, 2017)Objective: Levetiracetam is a new generation antiepileptic drug used in treatment of patients with epilepsy and has adverse effects on different tissues. We aimed to evaluate the apoptotic effects of levetiracetam exposure ... -
Evaluation of MIF-173 G/C Polymorphism in Turkish Patients with Ankylosing Spondylitis
Gurel, Cevik; Inanir, Ahmet; Nural, Ayse Feyda; Tekcan, Akin; Rustemoglu, Aydin; Yigit, Serbulent (GALENOS YAYINCILIK, 2016)Background: Ankylosing spondylitis (AS) is a chronic inflammatory disease mainly affecting the spine and sacroiliac joints. Macrophage migration inhibitory (MIF) factor is a regulatory cytokine that inhibits random immune ... -
Genotoxic Effects of Prenatal Exposure to Levetiracetam During Pregnancy on Rat Offsprings
Tural, Sengul; Tekcan, Akin; Elbistan, Mehmet; Karakus, Nevin; Ozyurek, Hamit; Kara, Nurten (INT INST ANTICANCER RESEARCH, 2015)Levetiracetam is a new-generation antiepileptic drug initially approved as an adjunctive treatment for patients with refractory partial seizures and is now also used as a monotherapy. The aim of this study was to evaluate ... -
The IL-1Ra gene variable number tandem repeat variant is associated with susceptibility to temporomandibular disorders in Turkish population
Tumer, Mehmet Kemal; Nursal, Ayse Feyda; Tekcan, Akin; Yerliyurt, Kaan; Geyko, Anastasia; Yigit, Serbulent (WILEY, 2018)BackgroundTemporomandibular joint disorders (TMD) are a group of disorders involving temporomandibular joint and related structures. Interleukine-1 receptor antagonist (IL-1Ra) is an important anti-inflammatory molecule ... -
Importance of NPC1 Gene 644 A -> G Mutation in Coronary Artery Disease
Ozturk, Sibel Demir; Celik, Atac; Nursal, Ayse Feyda; Tekcan, Akin; Rustemoglu, Aydin; Karakus, Nevin; Yigit, Serbulent (KAMLA-RAJ ENTERPRISES, 2017)Coronary artery disease (CAD) is the most prominent cause of mortality worldwide. The basis of CAD pathogenesis is the occlusion of coroner vessels progressively due to atherosclerotic plaques. NPCI gene plays a critical ... -
In Silico Analysis of FMR1 Gene Missense SNPs
Tekcan, Akin (HUMANA PRESS INC, 2016)The FMR1 gene, a member of the fragile X-related gene family, is responsible for fragile X syndrome (FXS). Missense single-nucleotide polymorphisms (SNPs) are responsible for many complex diseases. The effect of FMR1 gene ... -
Interleukin-1Ra rs2234663 and Interleukin-4 rs79071878 Polymorphisms in Familial Mediterranean Fever
Nursal, Ayse Feyda; Tekcan, Akin; Kaya, Suheyla Uzun; Sezer, Ozlem; Yigit, Serbulent (ELSEVIER SCIENCE BV, 2016)Objective: Familial Mediterranean Fever (FMF) is an autosomal recessively inherited auto inflammatory disorder. MEFV gene, causing FMF, encodes pyrin that is associated with the interleukin-1 (IL-1) related inflammation ... -
The investigation of association between IL-1Ra and ACE I/D polymorphisms in carpal tunnel syndrome
Cevik, Betul; Tekcan, Akin; Inanir, Ahmet; Kurt, Semiha Gulsum; Yigit, Serbulent (WILEY, 2018)BackgroundCarpal tunnel syndrome (CTS) is a common neurologic impairment caused by injury on the median nerve in the wrist, characterized by pain and loss of sensory. CTS usually occurs through three factors, such as a ... -
Investigation of CD40 gene rs4810485 and rs1883832 mutations in patients with recurrent aphthous stomatitis
Yigit, Serbulent; Tekcan, Akin; Rustemoglu, Aydin; Tumer, Mehmet Kemal; Kalkan, Goknur; Yerliyurt, Kaan (PERGAMON-ELSEVIER SCIENCE LTD, 2017)Objectives: Recurrent aphthous stomatitis (RAS) is a common painful disorder affecting oral health, mucosa and overall quality of life. The etiopathogenesis of RAS remains unclear. RAS shows a large genetic diversity among ... -
Macrophage Migration Inhibitory Factor-173GC Variant Might Increase the Risk of Behcet's Disease
Nursal, Ayse Feyda; Yigit, Serbulent; Tural, Ercan; Kalkan, Goknur; Tumer, Mehmet Kemal; Tekcan, Akin (KARGER, 2018)Objective: The aim of the present study was to investigate any possible association between the macrophage migration inhibitory factor (MIF) -173GC variant and Behcet's disease (BD) in a group of Turkish patients. Subjects ... -
Mutational Spectrum of the MEFV Gene in AA Amyloidosis Associated With Familial Mediterranean Fever
Nursal, Ayse Feyda; Tekcan, Akin; Kaya, Suheyla Uzun; Turkmen, Ercan; Yigit, Serbulent (IRANIAN SOC NEPHROLGY, 2016)Introduction. Familial Mediterranean fever (FMF) is a recessively inherited disease which is characterized by recurrent episodic fever, abdominal pain, and polyserositis. It is caused by mutations in the MEFV gene, encoding ... -
Relationship between major depressive disorder and ACE gene I/D polymorphism in a Turkish population
Inanir, Sema; Yigit, Serbulent; Celikel, Feryal Cam; Ates, Omer; Taycan, Serap Erdogan; Nursal, Ayse Feyda; Tekcan, Akin (UNIV SAO PAULO, INST PSIQUIATRIA, 2016)Background: Major depressive disorder (MDD) is a complex disease and a significant health problem that is prevalent across the world. Angiotensin-converting enzyme (ACE) has an important role in renin-angiotensin system ...
