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Acetohydroxyacid Synthase (AHAS) Inhibitor-Based Commercial Sulfonylurea Herbicides as Glutathione Reductase Inhibitors: in Vitro and in Silico Studies
Sel, Sedat; Tunç, Turgay; Ortaakarsu, Ahmet Buğra; Mamaş, Serhat; Karacan, Nurcan; Karacan, Mehmet Sayım (John Wiley and Sons Inc, 2022)In this study, in vitro inhibitory effect of AHAS inhibiting-based commercial sulfonylurea herbicides on human GR and S. cerevisiae GR was determined by electrochemical method. Our findings, the first report in literature, ... -
Influence of Chirality of Benzimidazole Amine Hybrids on Inhibition of Human Erythrocytes Carbonic Anhydrase I, II and Acetylcholinesterase
Tunç, Turgay; Abdurrahmanoğlu, Suzan; Günel, Aslıhan; Alım, Zuhal (John Wiley and Sons Inc, 2023)Novel chiral benzimidazole amine hybrids (4a–4d) were synthesized from commercially available amine [(R)- (+)-phenylethylamine, (−) (S)-(-)-phenylethylamine, (−) (R)-(-)-cyclohexylethylamine, (S)-(+)-cyclohexylethylamine] ... -
New Schiff bases with a 2,6-bis(2-aminophenylthio)pyridine moiety acting as glutathione reductase activator and inhibitors: Synthesis and molecular docking studies
Tunç, Turgay; Ortaakarsu, Ahmet Buğra; Hatipoğlu, Seda Muhsir; Kazancı, Uğur; Karaböcek, Serdar; Dege, Necmi; Karacan, Nurcan (Elsevier B.V., 2022)2,6-bis(2-aminophenylthio)pyridine was synthesized and identified by x-ray diffraction method. Its new Schiff bases (H2L1, H2L2, L3 and L4) were synthesized and characterized by elemental analysis, FT-IR, LC-MS, 1H NMR and ... -
New Schiffbases with a 2,6-bis(2-aminophenylthio)pyridine moiety acting as glutathione reductase activator and inhibitors: Synthesis and molecular docking studies
Tunç, Turgay; Ortaakarsu, Ahmet Buğra; Hatipoğlu, Seda Muhsir; Kazancı, Uğur; Karaböcek, Serdar; Karaböcek, Nevin; Dege, Necmi; Karacan, Nurcan (Elsevier, 2022)2,6-bis(2-aminophenylthio)pyridine was synthesized and identified by x-ray diffraction method. Its new Schiffbases (H2L1, H2L2, L-3 and L-4) were synthesized and characterized by elemental analysis, FT-IR, LC-MS, H-1 NMR ... -
Synthesis and Antibacterial Activity of New Chiral Aminoalcohol and Benzimidazole Hybrids
Çiçek, İlknur; Tunç, Turgay; Öğütçü, Hatice; Abdurrahmanoglu, Suzan; Günel, Aslıhan; Demirel, Nadir (Wiley-Blackwell, 2020)New chiral aminoalcohol-benzimidazole hybrids have been synthesized from commercially available aminoalcohols. [S(+)-Phenylglycinol, S(−)- Phenylalaninol and S(+)- Leuicinol] and 2-(chloromethyl)-N-tosyl-1-H-benzimidazole. ... -
Synthesis and antimicrobial study of new benzimidazole schiff bases bearing P-toluene sulfonamide moiety
Tunç, Turgay (Sociedad Chilena de Quimica, 2019)Three new Schiff bases bearing benzimidazole and p-toluen sulfonamide moiety were synthesized. Their structures were characterized by elemental analysis, FTIR, NMR and LCMS methods. The antimicrobial properties of the ... -
Synthesis of benzimidazole derivatives containing amide bond and biological evaluation as acetylcholinesterase, carbonic anhydrase I and II inhibitors
Alım, Zuhal; Tunç, Turgay; Demirel, Nadir; Günel, Aslıhan; Karacan, Nurcan (Elsevier B.V., 2022)Acetylcholinesterase (AChE) and carbonic anhydrase I (CA-I) and II (CA-II) are two vital metabolic enzymes. AChE inhibitors are seen as target molecules in drug development studies for Alzheimer's treatment. CA inhibitors ... -
Synthesis of New Schiff Bases and Assessment of Their in vitro Biological Effects on Acetylcholinesterase and Carbonic Anhydrase Isoenzymes Activities
Tunç, Turgay; Alım, Zuhal (Pleiades journals, 2021)Abstract: In this study, three new Schiff bases have been synthesized by the reactions of commercially available phenylglycinol, phenylalaninol, and leuicinol with 4-{[2-(4-formylphenoxy)ethyl](methyl)amin}benzaldehyde and ...