Yazar "Unsoy, Gozde" için listeleme
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Association between XRCC3 Thr241Met polymorphism and laryngeal cancer susceptibility in Turkish population
Mutlu, Pelin; Mutlu, Murad; Yalcin, Serap; Yaylaci, Atilay; Unsoy, Gozde; Saylam, Guleser; Akm, Istemihan (SPRINGER, 2015)DNA repair systems are essential for normal cell function. Genetic alterations in the DNA repair genes such as X-ray repair cross-complementing group 3 (XRCC3), can cause a change in protein activity which results in cancer ... -
Chitosan magnetic nanoparticles for pH responsive Bortezomib release in cancer therapy
Unsoy, Gozde; Yalcin, Serap; Khodadust, Rouhollah; Mutlu, Pelin; Onguru, Onder; Gunduz, Ufuk (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2014)The use of nanotechnology in cancer treatment offers exciting opportunities, including the possibility of destroying tumors with minimal damage to healthy tissue by novel targeted drug delivery systems. pH differences ... -
Detection of XRCC1 gene polymorphisms in Turkish head and neck squamous cell carcinoma patients: a comparative analysis with different populations
Mutlu, Pelin; Mutlu, Murad; Yalcin, Serap; Unsoy, Gozde; Yaylaci, Atilay; Saylam, Guleser; Akin, Istemihan (IMPRIMATUR PUBLICATIONS, 2015)Purpose: X-ray repair cross-complementing (XRCC1) is one of the most important genes for the maintenance of genomic integrity and protection of cells from DNA damage. Although tobacco and alcohol consumption are the major ... -
Effect of gemcitabine and retinoic acid loaded PAMAM dendrimer-coated magnetic nanoparticles on pancreatic cancer and stellate cell lines
Yalcin, Serap; Erkan, Mert; Unsoy, Gozde; Parsian, Maryam; Kleeff, Jorg; Gunduz, Ufuk (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2014)Gemcitabine is an anticancer drug used in the treatment of different cancer types, including pancreatic ductal adenocarcinoma. The maximum tolerated dose in humans is restricted by its side effects on healty cells. ... -
Idarubicin-loaded folic acid conjugated magnetic nanoparticles as a targetable drug delivery system for breast cancer
Gunduz, Ufuk; Keskin, Tugba; Tansik, Gulistan; Mutlu, Pelin; Yalcin, Serap; Unsoy, Gozde; Yakar, Arzu (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2014)Conventional cancer chemotherapies cannot differentiate between healthy and cancer cells, and lead to severe side effects and systemic toxicity. Another major problem is the drug resistance development before or during the ... -
Loading of Gemcitabine on chitosan magnetic nanoparticles increases the anti-cancer efficacy of the drug
Parsian, Maryam; Unsoy, Gozde; Mutlu, Pelin; Yalcin, Serap; Tezcaner, Aysen; Gunduz, Ufuk (ELSEVIER SCIENCE BV, 2016)Targeted delivery of anti-cancer drugs increase the efficacy, while decreasing adverse effects. Among various delivery systems, chitosan coated iron oxide nanoparticles (CsMNPs) gained attention with their biocompatibility, ... -
PAMAM dendrimer-coated iron oxide nanoparticles: synthesis and characterization of different generations
Khodadust, Rouhollah; Unsoy, Gozde; Yalcin, Serap; Gunduz, Gungor; Gunduz, Ufuk (SPRINGER, 2013)This study focuses on the synthesis and characterization of different generations (G(0)-G(7)) of polyamidoamine (PAMAM) dendrimer-coated magnetic nanoparticles (DcMNPs). In this study, superparamagnetic iron oxide nanoparticles ... -
Polyhydroxybutyrate-Coated Magnetic Nanoparticles for Doxorubicin Delivery: Cytotoxic Effect Against Doxorubicin-Resistant Breast Cancer Cell Line
Yalcin, Serap; Unsoy, Gozde; Mutlu, Pelin; Khodadust, Rouhollah; Gunduz, Ufuk (LIPPINCOTT WILLIAMS & WILKINS, 2014)In this study, polyhydroxybutyrate (PHB)-coated magnetic nanoparticles (MNPs) were prepared by coprecipitation of iron salts (Fe2+ and Fe3+) by ammonium hydroxide. Characterizations of PHB-coated MNPs were performed by ... -
Polyinosinic: polycytidylic acid loading onto different generations of PAMAM dendrimer-coated magnetic nanoparticles
Khodadust, Rouhollah; Mutlu, Pelin; Yalcin, Serap; Unsoy, Gozde; Gunduz, Ufuk (SPRINGER, 2013)Poly (I:C), which is a synthetic double-stranded RNA, have significant toxicity on tumor cells. The immobilization of Poly (I:C) onto nanoparticles is important for the fabrication of targeted delivery systems. In this ... -
Synthesis and Characterization of Polyhydroxybutyrate Coated Magnetic Nanoparticles: Toxicity Analyses on Different Cell Lines
Yalcin, Serap; Khodadust, Rouhollah; Unsoy, Gozde; Garip, Immihan Ceren; Mumcuoglu, Zahide Didem; Gunduz, Ufuk (TAYLOR & FRANCIS INC, 2015)In this study, polyhydroxybutyrate (PHB) coated magnetic nanoparticles were prepared which are targetable to tumor cells in the presence of a magnetic field. The structural properties, functional groups, size distribution, ... -
Synthesis of Doxorubicin loaded magnetic chitosan nanoparticles for pH responsive targeted drug delivery
Unsoy, Gozde; Khodadust, Rouhollah; Yalcin, Serap; Mutlu, Pelin; Gunduz, Ufuk (ELSEVIER SCIENCE BV, 2014)Targeted drug delivery is a promising alternative to overcome the limitations of classical chemotherapy. In an ideal targeted drug delivery system carrier nanoparticles would be directed to the tumor tissue and selectively ... -
Synthesis optimization and characterization of chitosan-coated iron oxide nanoparticles produced for biomedical applications
Unsoy, Gozde; Yalcin, Serap; Khodadust, Rouhollah; Gunduz, Gungor; Gunduz, Ufuk (SPRINGER, 2012)The chitosan-coated magnetic nanoparticles (CS MNPs) were in situ synthesized by cross-linking method. In this method; during the adsorption of cationic chitosan molecules onto the surface of anionic magnetic nanoparticles ...
