Yazar "Yalçın, Serap" için listeleme
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The -137G/C Polymorphism in Interleukin-18 Gene Promoter Contributes to Chronic Lymphocytic and Chronic Myelogenous Leukemia Risk in Turkish Patients
Amaç: İnterlökin-18 (İL-18), İL-1 süper ailesine ait bir sitokin olup, bağışıklık sistemine ait olan ve olmayan çeşitli hücrelerden salınmaktadır. Yapılan çalışmalar, İL-18'in hem anti-kanser hem de kansere öncülük eden ... -
Alginate-based bionanocomposites for cancer therapy
Yalçınkaya, Seda; Yalçın, Serap (Elsevier, 2022)Alginate is a natural polymer widely produced by extraction from brown seaweeds. In recent years, the alginate-based systems have been designed and characterized as gels, matrices, membranes, beads, pellets, fibers, ... -
Antiproliferative activity and interaction with proteins of N-cyclohexylacrylamide
Çankaya, Nevin; Yalçın, Serap (Elsevier B.V., 2022)N-cyclohexylacrylamıde (NCA), the synthesized compound, was evaluated for their cytotoxic activities against HeLa cancer cell line. Also, the current study has been analyzed by the use of molecular docking as protein-ligand ... -
Antiproliferative Effect of Organoclay, Poly(NCA) and their Nanocomposites on Hela Cell Line
Çankaya, Nevin; Vurgun, Bahar; Yalçın, Serap (Springer Science and Business Media Deutschland GmbH, 2021)In this study, the synthesis, characterization and thermal properties of poly(N-cyclohexylacrylamide) polymer/organoclay-based nanocomposites were investigated by in situ polymerization. FTIR, XRD, SEM and TGA techniques ... -
Characterization of gemcitabine loaded polyhydroxybutyrate coated magnetic nanoparticles for targeted drug delivery
Pars, Meryem; Mutlu, Pelin; Yalçın, Serap; Gündüz, Ufuk (Bentham Science Publishers, 2020)Background: Targeted drug delivery is one of the recent hot topics in cancer therapy. Because of having a targeting potential under the magnetic field and a suitable surface for the attachment of different therapeutic ... -
The Cisplatin, 5-fluorouracil, Irinotecan, and Gemcitabine Treatment in Resistant 2D and 3D Model Triple Negative Breast Cancer Cell Line: ABCG2 Expression Data
Ata, Fatma Kübra; Yalçın, Serap (Bentham Scıence Publ Ltd, 2022)Background: Chemotherapeutics have been commonly used in cancer treatment. Objective: In this study, the effects of Cisplatin, 5-fluorouracil, Irinotecan, and Gemcitabine have been evaluated on two-dimensional (2D) (sensitive ... -
Conformational, Structural, Vibrational, Electronic, and Molecular Docking Studies of 3-Formylphenylboronic Acid and 4-Formylphenylboronic Acid: A Comparative Study
Tanis, E.; Kurt, M.; Yalçın, Serap; Ercan, Fahriye (Maık Nauka/Interperıodıca/Sprınger, 2020)Phenylboronic acids are used as synthetic intermediates in organic synthesis Suzuki-Miyaura reaction is important for the synthesis of many inhibitors of serine proteases. Geometry optimization was performed for the eight ... -
The Cytotoxic Effect of Annona muricata-Loaded PHB-Coated Magnetic Nanoparticles on Cancer Cell Lines and Molecular Docking Analyses
Köksal, Rana; Yalçın, Serap (Ahi Evran Üniversitesi Fen Bilimleri Enstitü, 2020)In this study, we designed PHB-coated iron oxide–based nanoparticle for the delivery of Annona muricata to breast cancer cells and analyzed its therapeutic efficacy in vitro. The structural properties, functional groups, ... -
Determination of Potential Drug Candidate Molecules of the Hypericum perforatum for COVID-19 Treatment
Yalçın, Serap; Yalçınkaya, Seda; Ercan, Fahriye (Springer Science and Business Media Deutschland GmbH, 2021)The novel human coronavirus was firstly emerged in December 2019 in Wuhan, China, and has spread rapidly around the world. There is no known specific effective treatment of COVID-19. The most commonly used agents against ... -
Effect of bionanocomposites on human health
Yıldırım, Mehmethan; Yalçın, Serap (Elsevier, 2022)Nanotechnology is a major scientific area that has important potential to produce innovative material and this technology especially shows itself in biomedical research. Bionanocomposites occur with conjugates of biopolymers ... -
Exosomes as delivery tools in cancer therapy: Future perspectives
Ata, Fatma Kübra; Yalçın, Serap (Mashhad University of Medical Sciences, 2021)Exosomes, which are one of the extracellular vesicles, are considered necessary tools of intracellular communication that abundant in our body in physiological and pathological conditions with a diameter of 30-150 nm. The ... -
In Silico Detection Of İnhibitor Potential Of Passiflora Compounds Against SARS-Cov-2(Covid-19) Main Protease By Using Molecular Docking And Dynamic Analyses
Yalçın, Serap; Yalçınkaya, Seda; Ercan, Fahriye (Elsevier B.V., 2021)SARS-Cov-2(Covid-19) is a new strain of coronavirus and was firstly emerged in December 2019 in Wuhan, China. Now, there is no known specific treatment of Covid-19 available. COVID-19 main protease is a potential drug ... -
Mikrosistin Biyosentez Yolaklarının Düzenlenmesi and Genetik Mekanizmalar
Yalçın, Serap (2012)Oksijenik fotosentetik bakteriler grubunda yer alan, sucul ve karasal çevrede çok yaygın bir yaşam alanı bulunan siyanobakteriler (Mavi-yeşil alg) farklı morfolojik yapıya sahiptirler. Siyanobakteriler, bir kısmı oldukça ... -
Molecular Docking, Drug Likeness, and ADMET Analyses of Passiflora Compounds as P-Glycoprotein (P-gp) Inhibitor for the Treatment of Cancer
Yalçın, Serap (Springer Science and Business Media Deutschland GmbH, 2020)Cancer disease leads to deaths worldwide. Anti-cancer drugs have a high prevalence of side effects and cause multidrug resistance (MDR) that remains a significant barrier to major cancer therapy. To date, chemical and ... -
Poly (DL-lactic-co-glycolic acid) microparticle-Doxorubicin Formulations for Anti-cancer Drug Delivery
Kanser, hücrelerin kontrolsuz çoğalma ve yayılma özelliği kazandığı bir hastalıktır. Kanserin kemoterapi ile tedavisinde ilaçlar genelde sistemik olarak verilir ve kanser hücrelerinde toksik etkiye ulaşır. Ancak kanserli ... -
Preparation of Poly(MPAEMA)/Halloysite Nanocomposites and İnvestigation of Antiproliferative Activity
Çankaya, Nevin; Yalçın, Serap; Turan, Nevin (Sociedad Quimica de Mexico A.C., 2021)In this present work, the synthesis, characterization, and thermal properties of poly(2-(4-methoxyphenylamino)-2-oxoethyl methacrylate) (MPAEMA) polymer/clay-based nanocomposites were investigated by in-situ polymerization. ... -
Synthesis and biological activity of siRNA and Etoposide with magnetic nanoparticles on drug resistance model MCF-7 cells: Molecular docking study with MRP1 enzyme
Yalçın, Serap; Gündüz, Ufuk (Mashhad University of Medical Sciences, 2021)Objective(s): In this work, MRP-1 (Multidrug resistance-associated protein 1) gene expression levels and anticancer activity of siRNA and Etoposide loaded Poly-hydroxybutyrate (PHB) coated magnetic nanoparticles (MNPs) was ... -
Synthesis And Biological Activity of Sirna and Etoposide with Magnetic Nanoparticles on Drug Resistance Model MCF-7 Cells: Molecular Docking Study with MRP1 Enzyme
Yalçın, Serap; Gündüz, Ufuk (Mashhad Unıv Med Scıences, 2021)Objective(s): In this work, MRP-1 (Multidrug resistance-associated protein 1) gene expression levels and anticancer activity of siRNA and Etoposide loaded Poly-hydroxybutyrate (PHB) coated magnetic nanoparticles (MNPs) was ...
