Browsing by Author "Alım, Zuhal"
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Al-anbar ilindeki yetişkin erkek obez hastalarda glikozile hemoglobin ile insülin direnci arasındaki korelasyon
Jasım, Mosleh Nsaıf Jasım (Kırşehir Ahi Evran Üniversitesi, 2022)Obez yetişkin deneklerin vücut kitle indeksi (VKİ) 30 kg/m2 veya daha fazladır. Vücutta fazla yağ biriktiğinde genel sağlığı olumsuz etkiler. İnsülin direnci (IR), vücudun insülin üretiminin bozulduğu, hassas dokuların ... -
Evaluation of Inhibition Effects of Some Cardiovascular Therapeutics on Human Erythrocyte Carbonic Anhydrase Isoenzymes
Carbonic anhydrase enzyme plays a vital role in metabolic events such as acid-base regulation and respiration. In our research, it is tried to determine the inhibitory influences of the cardiovascular therapeutics esmolol ... -
Evaluation of Naphthalenylmethylen Hydrazine Derivatives as Potent Inhibitors on, Antiatherogenic Enzymes, Paraoxonase I and Acetylcholinesterase Activities
Shirinzadeh, Hanif; Dilek, Esra; Alım, Zuhal (Wıley-V C H Verlag Gmbh, 2022)Acetylcholinesterase (AChE) and paraoxonase 1 (PON1) are two important serum ester hydrolases that have antiatherosclerotic effect by inhibiting the oxidation of lipid peroxides. In addition, AChE inhibitors are target ... -
Evaluation of some thiophene-based sulfonamides as potent inhibitors of carbonic anhydrase I and II isoenzymes isolated from human erythrocytes by kinetic and molecular modelling studies
Alım, Zuhal; Köksal, Zeynep; Karaman, Muhammet (Sprınger Heidelberg, 2020)Background Thiophene(s) are an important group in therapeutic applications, and sulfonamides are the most important class of carbonic anhydrase (CA) inhibitors. In this study, inhibition effects of some thiophene-based ... -
Influence of Chirality of Benzimidazole Amine Hybrids on Inhibition of Human Erythrocytes Carbonic Anhydrase I, II and Acetylcholinesterase
Tunç, Turgay; Abdurrahmanoğlu, Suzan; Günel, Aslıhan; Alım, Zuhal (John Wiley and Sons Inc, 2023)Novel chiral benzimidazole amine hybrids (4a–4d) were synthesized from commercially available amine [(R)- (+)-phenylethylamine, (−) (S)-(-)-phenylethylamine, (−) (R)-(-)-cyclohexylethylamine, (S)-(+)-cyclohexylethylamine] ... -
Otizmde insülin degrade edici enzimin değerlendirilmesi, D vitamini ve bazı biyokimyasal parametrelerle ilişkisi
Abdulateef, Othman Ibrahım (Kırşehir Ahi Evran Üniversitesi, 2023)Bu çalışmanın temel amacı, Iraklı otizm hastalarında, insülin degrade edici enzim (IDE) ile D vitamini konsantrasyonu, glukoz konsantrasyonu, lipid konsantrasyonu (Kolesterol, Trigliserit, HDL, LDL ve VLDL), bazı antioksidan ... -
Physical–chemical studies of new, versatile carbazole derivatives and zinc complexes: Their synthesis, investigation of in vitro inhibitory effects on α-glucosidase and human erythrocyte carbonic anhydrase I and II isoenzymes
Çöl, Sümeyye; Emirik, Mustafa; Alım, Zuhal; Baran, Arif (John Wiley and Sons Ltd, 2022)In this study, two novel zinc–phthalocyanine complexes (4a and 6a), containing carbazole rings, were investigated. The first phthalocyanine 4a has been synthesized from 4-(2-(3-acetyl-9H-carbazol-9-yl)ethoxy at the peripheral ... -
Synthesis of benzimidazole derivatives containing amide bond and biological evaluation as acetylcholinesterase, carbonic anhydrase I and II inhibitors
Alım, Zuhal; Tunç, Turgay; Demirel, Nadir; Günel, Aslıhan; Karacan, Nurcan (Elsevier B.V., 2022)Acetylcholinesterase (AChE) and carbonic anhydrase I (CA-I) and II (CA-II) are two vital metabolic enzymes. AChE inhibitors are seen as target molecules in drug development studies for Alzheimer's treatment. CA inhibitors ... -
Tip 2 diyabetin mikrovasküler komplikasyonunda inflamatuar hasarın potansiyel biyobelirteçleri olarak inaktif K vitamini bağımlı matriks gla proteinleri ve fetuin-A
Alnaylee, Jasım Awad Abdoun (Kırşehir Ahi Evran Üniversitesi, 2022)Tip 2 Diyabetes Mellitus (T2DM) hastalarında vasküler kalsifikasyon mekanizmaları ile mortalite ilişkisi tam olarak anlaşılamamıştır. Arteriyel kalsifikasyonlar ve sertlik gibi makrodolaşım özellikleri, K vitamini durumunun ... -
A versatile study of novel A3B-type unsymmetric zinc(II) phthalocyanines containing thiazolidin-4-one: Their, carbonic anhydrase I, II isoenzymes, and xanthine oxidase inhibitors evaluation
Karakılıç, Emel; Alım, Zuhal; Günel, Aslıhan; Baran, Arif (Elsevier B.V., 2022)In this study, four novel phthalocyanine complexes containing zinc metal were synthesized. After preparing the starting compounds (2-(4-hydroxyphenyl)-3-phenylthiazolidin-4-one 1 and 2-(4-(2-hydroxyethoxy)phenyl)-3-pheny ...
