Browsing by Author "Gunduz, Ufuk"
Now showing items 1-16 of 16
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APOBEC3B expression in drug resistant MCF-7 breast cancer cell lines
Onguru, Onder; Yalcin, Serap; Rosemblit, Cinthia; Zhang, Paul J.; Kilic, Selim; Gunduz, Ufuk (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2016)APOBEC3B belongs to a protein family of cytidine deaminases that can insert mutations in DNA and RNA as a result of their ability to deaminate cytidine to uridine. It has been shown that APOBEC3B-catalysed deamination ... -
Chitosan magnetic nanoparticles for pH responsive Bortezomib release in cancer therapy
Unsoy, Gozde; Yalcin, Serap; Khodadust, Rouhollah; Mutlu, Pelin; Onguru, Onder; Gunduz, Ufuk (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2014)The use of nanotechnology in cancer treatment offers exciting opportunities, including the possibility of destroying tumors with minimal damage to healthy tissue by novel targeted drug delivery systems. pH differences ... -
DETERMINATION OF THE RELATIONSHIP BETWEEN DOXORUBICIN RESISTANCE AND WNT SIGNALING PATHWAY IN HELA AND K562 CELL LINES
Mutlu, Pelin; Azarkan, Serap Yalcin; Pourianazar, Negar Taghavi; Yucel, Meral; Gunduz, Ufuk (EXCLI JOURNAL MANAGING OFFICE, 2018)Activation of the Wnt signaling in some types of cancer and its relation with chemotherapy resistance is a very interesting issue that has been emphasized in recent years. Although, it is known that increase in the activity ... -
Effect of gemcitabine and retinoic acid loaded PAMAM dendrimer-coated magnetic nanoparticles on pancreatic cancer and stellate cell lines
Yalcin, Serap; Erkan, Mert; Unsoy, Gozde; Parsian, Maryam; Kleeff, Jorg; Gunduz, Ufuk (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2014)Gemcitabine is an anticancer drug used in the treatment of different cancer types, including pancreatic ductal adenocarcinoma. The maximum tolerated dose in humans is restricted by its side effects on healty cells. ... -
Folic acid functionalized PEG coated magnetic nanoparticles for targeting anti-cancer drug delivery: Preparation, characterization and cytotoxicity on Doxorubicin, Zoledronic acid and Paclitaxel resistant MCF-7 breast cancer cell lines
Keskin, Tugba; Yalcin, Serap; Gunduz, Ufuk (TAYLOR & FRANCIS INC, 2018)In this study, MNPs were synthesized, coated with biocompatible polyethylene glycol (PEG) and conjugated with folic acid. Crystal and chemical structures, shape, size and magnetic properties of synthesized nanoparticles ... -
Half generations magnetic PAMAM dendrimers as an effective system for targeted gemcitabine delivery
Parsian, Maryam; Mutlu, Pelin; Yalcin, Serap; Tezcaner, Aysen; Gunduz, Ufuk (ELSEVIER SCIENCE BV, 2016)Tumor-specific delivery of anticancer drugs by magnetic nanoparticles will maximize the efficacy of the drug and minimize side effects, and reduce systemic toxicity. The magnetic core of these nanoparticles provides an ... -
Idarubicin-loaded folic acid conjugated magnetic nanoparticles as a targetable drug delivery system for breast cancer
Gunduz, Ufuk; Keskin, Tugba; Tansik, Gulistan; Mutlu, Pelin; Yalcin, Serap; Unsoy, Gozde; Yakar, Arzu (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2014)Conventional cancer chemotherapies cannot differentiate between healthy and cancer cells, and lead to severe side effects and systemic toxicity. Another major problem is the drug resistance development before or during the ... -
Loading of Gemcitabine on chitosan magnetic nanoparticles increases the anti-cancer efficacy of the drug
Parsian, Maryam; Unsoy, Gozde; Mutlu, Pelin; Yalcin, Serap; Tezcaner, Aysen; Gunduz, Ufuk (ELSEVIER SCIENCE BV, 2016)Targeted delivery of anti-cancer drugs increase the efficacy, while decreasing adverse effects. Among various delivery systems, chitosan coated iron oxide nanoparticles (CsMNPs) gained attention with their biocompatibility, ... -
Nanoparticle-based drug delivery in cancer: the role of cell membrane structures
Yalcin, Serap; Ozluer, Ozlem; Gunduz, Ufuk (FUTURE SCI LTD, 2016)Development of novel drug-delivery systems aims to specifically deliver anticancer drugs to tumor tissues and improve the efficiency of chemotherapy, while minimizing side effects of drugs on healthy tissues and organs. ... -
PAMAM dendrimer-coated iron oxide nanoparticles: synthesis and characterization of different generations
Khodadust, Rouhollah; Unsoy, Gozde; Yalcin, Serap; Gunduz, Gungor; Gunduz, Ufuk (SPRINGER, 2013)This study focuses on the synthesis and characterization of different generations (G(0)-G(7)) of polyamidoamine (PAMAM) dendrimer-coated magnetic nanoparticles (DcMNPs). In this study, superparamagnetic iron oxide nanoparticles ... -
Polyhydroxybutyrate-Coated Magnetic Nanoparticles for Doxorubicin Delivery: Cytotoxic Effect Against Doxorubicin-Resistant Breast Cancer Cell Line
Yalcin, Serap; Unsoy, Gozde; Mutlu, Pelin; Khodadust, Rouhollah; Gunduz, Ufuk (LIPPINCOTT WILLIAMS & WILKINS, 2014)In this study, polyhydroxybutyrate (PHB)-coated magnetic nanoparticles (MNPs) were prepared by coprecipitation of iron salts (Fe2+ and Fe3+) by ammonium hydroxide. Characterizations of PHB-coated MNPs were performed by ... -
Polyinosinic: polycytidylic acid loading onto different generations of PAMAM dendrimer-coated magnetic nanoparticles
Khodadust, Rouhollah; Mutlu, Pelin; Yalcin, Serap; Unsoy, Gozde; Gunduz, Ufuk (SPRINGER, 2013)Poly (I:C), which is a synthetic double-stranded RNA, have significant toxicity on tumor cells. The immobilization of Poly (I:C) onto nanoparticles is important for the fabrication of targeted delivery systems. In this ... -
Synthesis and Characterization of Polyhydroxybutyrate Coated Magnetic Nanoparticles: Toxicity Analyses on Different Cell Lines
Yalcin, Serap; Khodadust, Rouhollah; Unsoy, Gozde; Garip, Immihan Ceren; Mumcuoglu, Zahide Didem; Gunduz, Ufuk (TAYLOR & FRANCIS INC, 2015)In this study, polyhydroxybutyrate (PHB) coated magnetic nanoparticles were prepared which are targetable to tumor cells in the presence of a magnetic field. The structural properties, functional groups, size distribution, ... -
Synthesis of Doxorubicin loaded magnetic chitosan nanoparticles for pH responsive targeted drug delivery
Unsoy, Gozde; Khodadust, Rouhollah; Yalcin, Serap; Mutlu, Pelin; Gunduz, Ufuk (ELSEVIER SCIENCE BV, 2014)Targeted drug delivery is a promising alternative to overcome the limitations of classical chemotherapy. In an ideal targeted drug delivery system carrier nanoparticles would be directed to the tumor tissue and selectively ... -
Synthesis optimization and characterization of chitosan-coated iron oxide nanoparticles produced for biomedical applications
Unsoy, Gozde; Yalcin, Serap; Khodadust, Rouhollah; Gunduz, Gungor; Gunduz, Ufuk (SPRINGER, 2012)The chitosan-coated magnetic nanoparticles (CS MNPs) were in situ synthesized by cross-linking method. In this method; during the adsorption of cationic chitosan molecules onto the surface of anionic magnetic nanoparticles ... -
Telomere 1 (POT1) gene expression and its association with telomerase activity in colorectal tumor samples with different pathological features
Izgi, Ahu; Gunal, Armagan; Yalcin, Serap; Gunduz, Ufuk (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2014)The ends of chromosoms, telomeres are bound with a number of proteins which protect and stabilize telomeres against degredation, end to end fusion and aberrant recombinations. Telomeric DNA is bound of two groups of proteins, ...
