Browsing by Author "Koca, İrfan"

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Pyrazolyl-Benzoxazinone Derivatives as Dual Hsp Inhibitors in Human Breast Cancer

Koca, İrfan; Kamacı, Volkan; Özsoy, Ceylan; ...; Kani, İbrahim; Tutar, Lütfi; Tutar, Yusuf (John Wiley and Sons Inc, 2022)

Heat Shock Proteins (Hsps) play major role on the onset of several cancers. Metabolic rates of cancer cells are higher compared to that of untransformed cells. This accelerated rate force functional substrate proteins to ...
Triad Pyrazole–Thiazole–Coumarin Heterocyclic Core Effectively İnhibit HSP and Drive Cancer Cells to Apoptosis

Gümüş, Mehmet; Koca, İrfan; Sert, Yusuf; Yenilmez Tunoğlu, Ezgi Nurdan; Tutar, Lütfi; Tutar, Yusuf (Taylor and Francis Ltd., 2023)

Intensive studies on hepatocellular carcinoma (HCC), which is spreading rapidly around the world and has a high mortality rate, is due to the lack of adequate preventive or curative treatment methods. Treating patients ...