Browsing by Author "Mutlu, Pelin"
Now showing items 1-15 of 15
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The -137G/C Polymorphism in Interleukin-18 Gene Promoter Contributes to Chronic Lymphocytic and Chronic Myelogenous Leukemia Risk in Turkish Patients
Amaç: İnterlökin-18 (İL-18), İL-1 süper ailesine ait bir sitokin olup, bağışıklık sistemine ait olan ve olmayan çeşitli hücrelerden salınmaktadır. Yapılan çalışmalar, İL-18'in hem anti-kanser hem de kansere öncülük eden ... -
Association between XRCC3 Thr241Met polymorphism and laryngeal cancer susceptibility in Turkish population
Mutlu, Pelin; Mutlu, Murad; Yalcin, Serap; Yaylaci, Atilay; Unsoy, Gozde; Saylam, Guleser; Akm, Istemihan (SPRINGER, 2015)DNA repair systems are essential for normal cell function. Genetic alterations in the DNA repair genes such as X-ray repair cross-complementing group 3 (XRCC3), can cause a change in protein activity which results in cancer ... -
Association of-174G/C interleukin-6 gene polymorphism with the risk of chronic lymphocytic, chronic myelogenous and acute myelogenous leukemias in Turkish patients
Mutlu, Pelin; Yalcin, Serap; Elci, Pinar; Yildirim, Murat; Cetin, A. Turker; Avcu, Ferit (ZERBINIS MEDICAL PUBL, 2014)Purpose: The purpose of this study was to evaluate the relationship between -174G/C interleukin-6 (IL-6) gene promoter polymorphism and susceptibility to chronic lymphocytic (CLL), chronic myelogenous (CML) and acute ... -
Characterization of gemcitabine loaded polyhydroxybutyrate coated magnetic nanoparticles for targeted drug delivery
Pars, Meryem; Mutlu, Pelin; Yalçın, Serap; Gündüz, Ufuk (Bentham Science Publishers, 2020)Background: Targeted drug delivery is one of the recent hot topics in cancer therapy. Because of having a targeting potential under the magnetic field and a suitable surface for the attachment of different therapeutic ... -
Chitosan magnetic nanoparticles for pH responsive Bortezomib release in cancer therapy
Unsoy, Gozde; Yalcin, Serap; Khodadust, Rouhollah; Mutlu, Pelin; Onguru, Onder; Gunduz, Ufuk (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2014)The use of nanotechnology in cancer treatment offers exciting opportunities, including the possibility of destroying tumors with minimal damage to healthy tissue by novel targeted drug delivery systems. pH differences ... -
Detection of XRCC1 gene polymorphisms in Turkish head and neck squamous cell carcinoma patients: a comparative analysis with different populations
Mutlu, Pelin; Mutlu, Murad; Yalcin, Serap; Unsoy, Gozde; Yaylaci, Atilay; Saylam, Guleser; Akin, Istemihan (IMPRIMATUR PUBLICATIONS, 2015)Purpose: X-ray repair cross-complementing (XRCC1) is one of the most important genes for the maintenance of genomic integrity and protection of cells from DNA damage. Although tobacco and alcohol consumption are the major ... -
DETERMINATION OF THE RELATIONSHIP BETWEEN DOXORUBICIN RESISTANCE AND WNT SIGNALING PATHWAY IN HELA AND K562 CELL LINES
Mutlu, Pelin; Azarkan, Serap Yalcin; Pourianazar, Negar Taghavi; Yucel, Meral; Gunduz, Ufuk (EXCLI JOURNAL MANAGING OFFICE, 2018)Activation of the Wnt signaling in some types of cancer and its relation with chemotherapy resistance is a very interesting issue that has been emphasized in recent years. Although, it is known that increase in the activity ... -
Half generations magnetic PAMAM dendrimers as an effective system for targeted gemcitabine delivery
Parsian, Maryam; Mutlu, Pelin; Yalcin, Serap; Tezcaner, Aysen; Gunduz, Ufuk (ELSEVIER SCIENCE BV, 2016)Tumor-specific delivery of anticancer drugs by magnetic nanoparticles will maximize the efficacy of the drug and minimize side effects, and reduce systemic toxicity. The magnetic core of these nanoparticles provides an ... -
Idarubicin-loaded folic acid conjugated magnetic nanoparticles as a targetable drug delivery system for breast cancer
Gunduz, Ufuk; Keskin, Tugba; Tansik, Gulistan; Mutlu, Pelin; Yalcin, Serap; Unsoy, Gozde; Yakar, Arzu (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2014)Conventional cancer chemotherapies cannot differentiate between healthy and cancer cells, and lead to severe side effects and systemic toxicity. Another major problem is the drug resistance development before or during the ... -
Investigation of the Therapeutic Effects of Palbociclib Conjugated Magnetic Nanoparticles on Different Types of Breast Cancer Cell Lines
Parsian, Maryam; Mutlu, Pelin; Pourianazar, Negar Taghavi; Azarkan, Serap Yalcin; Gündüz, Ufuk (Springer, 2023)Introduction-Drug targeting and controlled drug release systems in cancer treatment have many advantages over conventional chemotherapy in terms of limiting systemic toxicity, side effects, and overcoming drug resistance.Methods ... -
Loading of Gemcitabine on chitosan magnetic nanoparticles increases the anti-cancer efficacy of the drug
Parsian, Maryam; Unsoy, Gozde; Mutlu, Pelin; Yalcin, Serap; Tezcaner, Aysen; Gunduz, Ufuk (ELSEVIER SCIENCE BV, 2016)Targeted delivery of anti-cancer drugs increase the efficacy, while decreasing adverse effects. Among various delivery systems, chitosan coated iron oxide nanoparticles (CsMNPs) gained attention with their biocompatibility, ... -
Polyhydroxybutyrate-Coated Magnetic Nanoparticles for Doxorubicin Delivery: Cytotoxic Effect Against Doxorubicin-Resistant Breast Cancer Cell Line
Yalcin, Serap; Unsoy, Gozde; Mutlu, Pelin; Khodadust, Rouhollah; Gunduz, Ufuk (LIPPINCOTT WILLIAMS & WILKINS, 2014)In this study, polyhydroxybutyrate (PHB)-coated magnetic nanoparticles (MNPs) were prepared by coprecipitation of iron salts (Fe2+ and Fe3+) by ammonium hydroxide. Characterizations of PHB-coated MNPs were performed by ... -
Polyinosinic: polycytidylic acid loading onto different generations of PAMAM dendrimer-coated magnetic nanoparticles
Khodadust, Rouhollah; Mutlu, Pelin; Yalcin, Serap; Unsoy, Gozde; Gunduz, Ufuk (SPRINGER, 2013)Poly (I:C), which is a synthetic double-stranded RNA, have significant toxicity on tumor cells. The immobilization of Poly (I:C) onto nanoparticles is important for the fabrication of targeted delivery systems. In this ... -
Synthesis of Doxorubicin loaded magnetic chitosan nanoparticles for pH responsive targeted drug delivery
Unsoy, Gozde; Khodadust, Rouhollah; Yalcin, Serap; Mutlu, Pelin; Gunduz, Ufuk (ELSEVIER SCIENCE BV, 2014)Targeted drug delivery is a promising alternative to overcome the limitations of classical chemotherapy. In an ideal targeted drug delivery system carrier nanoparticles would be directed to the tumor tissue and selectively ... -
The-137G/C Polymorphism in Interleukin-18 Gene Promoter Contributes to Chronic Lymphocytic and Chronic Myelogenous Leukemia Risk in Turkish Patients
Yalcin, Serap; Mutlu, Pelin; Cetin, Turker; Sarper, Meral; Ozgur, Gokhan; Avcu, Ferit (GALENOS YAYINCILIK, 2015)Objective: Interleuldn-18 (IL-18) is a cytokine that belongs to the IL-1 superfamily and is secreted by various immune and nonimmune cells. Evidence has shown that 1L-18 has both anticancer and procancer effects. The aim ...
