Browsing by Author "Tutar, Yusuf"
Now showing items 1-6 of 6
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Design, Synthesis, and Evaluation of Heat Shock Protein 90 Inhibitors in Human Breast Cancer and Its Metastasis
Gumus, Mehmet; Ozgur, Aykut; Tutar, Lutfi; Disli, Ali; Koca, Irfan; Tutar, Yusuf (BENTHAM SCIENCE PUBL LTD, 2016)Background: Despite development of novel cancer drugs, invasive ductal breast carcinoma and its metastasis are still highly morbid. Therefore, new therapeutic approaches are being developed and Hsp90 is an important target ... -
MicroRNAs and Heat Shock Proteins in Breast Cancer Biology
Yıldız, Mehmet Taha; Tutar, Lütfi; Giritlioğlu, Nazlı Irmak; Bayram, Banu; Tutar, Yusuf (Humana Press Inc., 2022)Breast cancer has five major immune types; luminal A, luminal B, HER2, Basal-like, and normal-like. Cells produce a family of protein called heat shock proteins (Hsps) in response to exposure to thermal and other proteotoxic ... -
Pyrazolyl-Benzoxazinone Derivatives as Dual Hsp Inhibitors in Human Breast Cancer
Koca, İrfan; Kamacı, Volkan; Özsoy, Ceylan; ...; Kani, İbrahim; Tutar, Lütfi; Tutar, Yusuf (John Wiley and Sons Inc, 2022)Heat Shock Proteins (Hsps) play major role on the onset of several cancers. Metabolic rates of cancer cells are higher compared to that of untransformed cells. This accelerated rate force functional substrate proteins to ... -
Triad Pyrazole–Thiazole–Coumarin Heterocyclic Core Effectively İnhibit HSP and Drive Cancer Cells to Apoptosis
Gümüş, Mehmet; Koca, İrfan; Sert, Yusuf; Yenilmez Tunoğlu, Ezgi Nurdan; Tutar, Lütfi; Tutar, Yusuf (Taylor and Francis Ltd., 2023)Intensive studies on hepatocellular carcinoma (HCC), which is spreading rapidly around the world and has a high mortality rate, is due to the lack of adequate preventive or curative treatment methods. Treating patients ... -
Tumor Targeting of Polymeric Nanoparticles Conjugated with Peptides, Saccharides, and Small Molecules for Anticancer Drugs
Bayram, Banu; Ozgur, Aykut; Tutar, Lutfi; Tutar, Yusuf (BENTHAM SCIENCE PUBL LTD, 2017)Targeting drugs or pharmaceutical compounds to tumor site increases cancer treatment efficiency and therapeutic outcome. Nanoparticles are unique delivery systems for site-targeting within an organism. Many novel technologies ...
