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Synthesis and Antibacterial Activity of New Chiral Aminoalcohol and Benzimidazole Hybrids
(Wiley-Blackwell, 2020)
New chiral aminoalcohol-benzimidazole hybrids have been synthesized from commercially available aminoalcohols. [S(+)-Phenylglycinol, S(−)- Phenylalaninol and S(+)- Leuicinol] and 2-(chloromethyl)-N-tosyl-1-H-benzimidazole. ...
A multi-spectroscopic, computational and molecular modeling studies on anti-apoptotic proteins with Boc-D-Lys-OH
(ELSEVIER, 2020)
Synthesized molecules have attracted much interest due their biological activity. Anti-apoptotic proteins such as BCL-2, BCL-w, MCL-1, AKT1 and BRAE have potential roles in apoptosis mechanism. Suppression of these ...
Molecular Docking, Drug Likeness, and ADMET Analyses of Passiflora Compounds as P-Glycoprotein (P-gp) Inhibitor for the Treatment of Cancer
(Springer Science and Business Media Deutschland GmbH, 2020)
Cancer disease leads to deaths worldwide. Anti-cancer drugs have a high prevalence of side effects and cause multidrug resistance (MDR) that remains a significant barrier to major cancer therapy. To date, chemical and ...
The Cytotoxic Effect of Annona muricata-Loaded PHB-Coated Magnetic Nanoparticles on Cancer Cell Lines and Molecular Docking Analyses
(Ahi Evran Üniversitesi Fen Bilimleri Enstitü, 2020)
In this study, we designed PHB-coated iron oxide–based nanoparticle for the delivery of Annona muricata to breast cancer cells and analyzed its therapeutic efficacy in vitro. The structural properties, functional groups, ...
