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In silico detection of inhibitor potential of Passiflora compounds against SARS-Cov-2(Covid-19) main protease by using molecular docking and dynamic analyses
(Elsevier, 2021)SARS-Cov-2(Covid-19) is a new strain of coronavirus and was firstly emerged in December 2019 in Wuhan, China. Now, there is no known specific treatment of Covid-19 available. COVID-19 main protease is a potential drug ... -
Synthesis, Characterization, Biological Evaluation and Molecular Docking Studies of New Oxoacrylate and Acetamide on HeLa Cancer Cell Lines
(Bentham Scıence Publ Ltd, 2021)Background: In recent years, the discovery and development of new drugs play a critical role in cancer therapy.Objective: In this study, the effect of MPAEA and p-acetamide on cellular toxicity and on silico in HeLa cancer ... -
Information and behaviors of patients applying to chest diseases outpatient clinic regarding rational use of drugs
(10.52142/OMUJECM.38.4.39, 38)Rational Drug Use (RUD), which aims to use drugs, when necessary, in the appropriate amount and in an appropriate way, is required from the physician with the rational choice of drugs and prescribing; health policies cover ... -
The Determination of Molecular and Toxicological Mechanisms of Cucur-bitacin E in Model Organism Drosophila melanogaster and Various Cancer Cell Lines: Molecular Modelling, Docking and Dynamic Simulation Studies
(Bentham Science Publishers, 2023)Introduction: Cucurbitacins are one of the most important components of Ecballium elaterium. Among the cucurbitacins, Cucurbitacin E was the first to be isolated. This study fo-cused on screening the anticancer and ... -
Exosomes as delivery tools in cancer therapy: Future perspectives
(Mashhad University of Medical Sciences, 2021)Exosomes, which are one of the extracellular vesicles, are considered necessary tools of intracellular communication that abundant in our body in physiological and pathological conditions with a diameter of 30-150 nm. The ... -
Synthesis and biological activity of siRNA and Etoposide with magnetic nanoparticles on drug resistance model MCF-7 cells: Molecular docking study with MRP1 enzyme
(Mashhad University of Medical Sciences, 2021)Objective(s): In this work, MRP-1 (Multidrug resistance-associated protein 1) gene expression levels and anticancer activity of siRNA and Etoposide loaded Poly-hydroxybutyrate (PHB) coated magnetic nanoparticles (MNPs) was ... -
Investigation of the Therapeutic Effects of Palbociclib Conjugated Magnetic Nanoparticles on Different Types of Breast Cancer Cell Lines
(Springer, 2023)Introduction-Drug targeting and controlled drug release systems in cancer treatment have many advantages over conventional chemotherapy in terms of limiting systemic toxicity, side effects, and overcoming drug resistance.Methods ... -
Molecular Docking, Drug Likeness, and ADMET Analyses of Passiflora Compounds as P-Glycoprotein (P-gp) Inhibitor for the Treatment of Cancer
(Springer Science and Business Media Deutschland GmbH, 2020)Cancer disease leads to deaths worldwide. Anti-cancer drugs have a high prevalence of side effects and cause multidrug resistance (MDR) that remains a significant barrier to major cancer therapy. To date, chemical and ... -
The Role of Cyclooxygenase Enzymes in the Effects of Losartan and Lisinopril on the Contractions of Rat Thoracic Aorta
(AVES, 2017)Objective: It was suggested that prostaglandins which are synthesized by cyclooxygenase (COX) enzymes contribute to the actions of angiotensin-converting enzyme (ACE) inhibition and angiotensin AT1 receptor antagonism and ... -
Protective role of resveratrol on testicular germ cells in mice with testicular toxicity
(AVES, 2017)Objective: The aim of the present study was to investigate the possible beneficial effects of resveratrol in mice subjected to vinyl cyclohexene dieposide (VCD) -induced testicular toxicity. Material and methods: A total ... -
Estrogen-like Activity of Quercetin in Female Rats
(AVES, 2016)Objective: Quercetin is a phytoestrogen that exerts both in vitro agonistic and antagonistic activities on estrogen receptors. The present study evaluated the in vivo estrogen-like activity of quercetin on the reproductive ... -
Estrogen modulating effects of resveratrol in female rats
(MARMARA UNIV, FAC MEDICINE, 2016)Objectives: This study investigates the estrogen-like effects of resveratrol (RES) in female rats. Materials and Methods: In this two-step study on estrogenlike activity of RES, immature female rats (21 days old) were used ...
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