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dc.contributor.authorSahin, Ayla
dc.contributor.authorEke, Gozde
dc.contributor.authorBuyuksungur, Arda
dc.contributor.authorHasirci, Nesrin
dc.contributor.authorHasirci, Vasif
dc.date.accessioned2019-11-24T20:38:17Z
dc.date.available2019-11-24T20:38:17Z
dc.date.issued2018
dc.identifier.issn0920-5063
dc.identifier.issn1568-5624
dc.identifier.urihttps://dx.doi.org/10.1080/09205063.2018.1423812
dc.identifier.urihttps://hdl.handle.net/20.500.12513/2500
dc.descriptionWOS: 000424943700004en_US
dc.descriptionPubMed ID: 29297759en_US
dc.description.abstractThe aim of this study was to target nano sized (266 +/- 25nm diameter) poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) particles carrying Doxorubicin (DOX), an anticancer agent, to human osteosarcoma cells (Saos-2). A nuclear targeting molecule (Nuclear Localization Signal, NLS), a 17 a.a. peptide, was attached onto the doxorubicin loaded nanoparticles. NLS conjugated nanoparticles surrounded the cell nuclei, but did not penetrate them. Free doxorubicinand doxorubicin loadednanoparticles entered the cytoplasm and were evenly distributed within the cytoplasm. The localization of the NLS-targetedparticles around the nuclear membrane caused a significantly higher decrease in the cancer cell numbers due to apoptosis or necrosis than the untargeted and free doxorubicin formulations showing the importance of targeting the nanoparticles to the nuclear membrane in the treatment of cancer.en_US
dc.description.sponsorshipMiddle East Technical University Center of Excellence in Biomaterials and Tissue Engineering (BIOMATEN)en_US
dc.description.sponsorshipThis work was financially supported by Middle East Technical University Center of Excellence in Biomaterials and Tissue Engineering (BIOMATEN).en_US
dc.language.isoengen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.isversionof10.1080/09205063.2018.1423812en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPHBVen_US
dc.subjectbiodegradable nanoparticlesen_US
dc.subjectnuclear drug deliveryen_US
dc.subjectdoxorubicinen_US
dc.subjectnuclear localization signalen_US
dc.titleNuclear targeting peptide-modified, DOX-loaded, PHBV nanoparticles enhance drug efficacy by targeting to Saos-2 cell nuclear membranesen_US
dc.typearticleen_US
dc.relation.journalJOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITIONen_US
dc.contributor.departmentKırşehir Ahi Evran Üniversitesi, Fen-Edebiyat Fakültesi, Kimya Bölümüen_US
dc.identifier.volume29en_US
dc.identifier.issue5en_US
dc.identifier.startpage507en_US
dc.identifier.endpage519en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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