Antimony(III) complexes with 2-amino-4,6-dimethoxypyrimidines: Synthesis, characterization and biological evaluation
Göster/Aç
Erişim
info:eu-repo/semantics/closedAccessTarih
2015Yazar
Tunc, TurgayKaracan, Mehmet Sayim
Ertabaklar, Hatice
Sari, Musa
Karacan, Nurcan
Buyukgungor, Orhan
36 readers on Mendeley
Üst veri
Tüm öğe kaydını gösterÖzet
Novel pyrimidine compound bearing disulfide bridge, 5,5'-disulfanediyIbis(2-amino-4,6-dimetoxypyrimidine) (3) was synthesized by reduction of 2-amino-4,6-dimethoxy-5-thiocyanatopyrimidine for the first time, and its structure was confirmed by X-ray crystallographic analysis. Novel binuclear antimony(III) compound of (3), {Sb[5,5'-disulfanediylbis(2-amino-4,6-dimetoxypyrimidine)]Cl-3}(2) (4) and mononuclear antimony(III) compounds, SbL2O3, [L: 2-amino-5-thioI-4,6-dimethoxy pyrimidine (2) and 2-amino-5-(1H-tetrazol-5-ylthio)-4,6-dimethoxypyrimidine (6)] were synthesized and characterized with the help of elemental analysis, molecular conductivity, FT-IR,H-1-NMR and LC-MS techniques. The geometrical structures optimized by a DFT/B3LYP/LANL2DZ method of the compounds, indicated that monomeric compounds have square pyramidal shape. Both antileishmanial activity against Leishmania tropica promastigote and glutathione reductase inhibitory activity were determined in vitro. The results showed that (3) has the best biological activity. (C) 2015 Elsevier B.V. All rights reserved.
Kaynak
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGYCilt
153Bağlantı
https://dx.doi.org/10.1016/j.jphotobiol.2015.09.022https://hdl.handle.net/20.500.12513/2531
Koleksiyonlar
- Scopus İndeksli Yayınlar Koleksiyonu [2488]
- WoS İndeksli Yayınlar Koleksiyonu [3138]
- Yayın Koleksiyonu [191]