Voltammetric Stripping Methods for Direct Determination of Disopyramide

Abstract

Electrochemical behavior of disopyramide (DPA) on glassy carbon electrode (GCE) was investigated by using cyclic voltammetry, square-wave voltammetry and constant potential bulk electrolysis. Adsorption and diffusion properties of DPA were evaluated. Differential pulse anodic adsorptive stripping voltammetric (DPAAdSV) and square-wave anodic adsorptive stripping voltammetric (SWAAdSV) methods were developed for its direct determination in pharmaceutical preparations and biological samples. Linear working concentration range for both methods was found as 3 x 10(-7) M (0.102 mg/L) - 3 x 10(-6) M (1.0 mg/L). Limit of detection and limit of quantitation for DPAAdSV were found to be 2.9 x 10(-7) M (0.10 mg/L) and 9.5 x 10(-7) M (0.32 mg/L), respectively and they were calculated to be 1.4 x 10(-7) M (0.05 mg/L) and 4.5 x 10(-7) M (0.15 mg/L) for SWAAdSV. Proposed methods were successfully applied to determine the content of DPA in pharmaceutical preparations and biological samples.