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dc.contributor.authorKarakılıç, Emel
dc.contributor.authorBaran, Şule
dc.contributor.authorÖğütçü, Hatice
dc.contributor.authorAkdemir, Atilla
dc.contributor.authorBaran, Arif
dc.date.accessioned2022-09-02T07:52:28Z
dc.date.available2022-09-02T07:52:28Z
dc.date.issued2020en_US
dc.identifier.citationKarakılıç, E., Baran, Ş., Öğütçü, H., Akdemir, A., & Baran, A. (2020). rac‐and meso‐Cyclohexanoids: Their α‐, β‐glycosidases, antibacterial, antifungal activities, and molecular docking studies. Archiv der Pharmazie, 353(3), 1900267.en_US
dc.identifier.issn03656233
dc.identifier.urihttps://doi.org/10.1002/ardp.201900267
dc.identifier.urihttps://hdl.handle.net/20.500.12513/4558
dc.description.abstractAn efficient and versatile synthesis method has been postulated for hydroxymethylated rac- and meso-cyclohexanoid derivatives. The synthesis of these stereoisomers was achieved easily with traditional methods using hexahydroisobenzofuran 6, prepared from commercially available cis-hydrophthalic anhydride. The study, involving diastereoselective epoxidation and cis-hydroxylation, was conducted to obtain epoxy-, cis-, and trans-diol-furans 7, 8, and 9. After sulfamic acid-catalyzed ring-opening reaction of the epoxide and furan rings, rac- and meso-tetraacetates 14, 15, and 16 were afforded. Hydrolysis of acetate groups with ammonia in absolute methanol yielded the desired tetrols rac-17, meso-18, and meso-19. All structures, after purification by chromatographic methods and elucidation by spectral techniques, were screened against α- and β-glucosidases. Compounds 7, 8, 10, 17, 18, and 19 were also evaluated for their antibacterial and antifungal activity against some selected synthesized compounds with varying degrees of inhibitory effects on the growth of different pathogenic microorganisms by the well-diffusion method. In addition, Saccharomyces cerevisiae α-glucosidase molecular modeling studies were performed for all rac- and meso-compounds 7, 8, 10, 17, 18, and 19. © 2020 Deutsche Pharmazeutische Gesellschaften_US
dc.language.isoengen_US
dc.publisherWiley-VCH Verlagen_US
dc.relation.isversionof10.1002/ardp.201900267en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectantifungal activityen_US
dc.subjectantimicrobial activityen_US
dc.subjectassayen_US
dc.subjectinhibitorsen_US
dc.titlerac- and meso-Cyclohexanoids: Their α-, β-glycosidases, antibacterial, antifungal activities, and molecular docking studiesen_US
dc.typearticleen_US
dc.relation.journalArchiv der Pharmazieen_US
dc.contributor.departmentZiraat Fakültesien_US
dc.contributor.authorIDHatice Öğütçü / 0000-0001-7100-9318en_US
dc.identifier.volume353en_US
dc.identifier.issue3en_US
dc.identifier.startpage1en_US
dc.identifier.endpage17en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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