Vitamin B12: An underestimated cause of acneiform drug eruption

Abstract

Dear Editor,Acneiform drug eruption is a type of adverse drug reaction character-ized by monomorphic papulopustular lesions. There are a limited num-ber of studies focusing on vitamin B12-induced acneiform eruption(BIAE) in the relevant literature.1,2In this study, we retrospectivelyanalyzed the clinical characteristics of BIAE in a consecutive series of32 patients who were admitted to the dermatology departments ofAhi Evran University and Kozan State Hospital over the last 3 years.Collected demographic and clinical data for each patient included age,sex, history of medication, previous experience with vitamin B12,symptoms, morphology, distribution and duration of the eruption, andthe treatment used. Causality assessment between vitamin B12intakeand BIAE was mainly based on the diagnostic criteria for drug reac-tions that have been originally proposed by Naranjo et al3For theselection of the 32 patients, the inclusion criteria were as follows...