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dc.contributor.authorKeçeciler Emir, Ceren
dc.contributor.authorİlhan Ayışıgı, Esra
dc.contributor.authorÇelen Erden, Çiğdem
dc.contributor.authorNalbantsoy, Ayşe
dc.contributor.authorYeşil Çeliktaş, Özlem
dc.date.accessioned2025-01-15T11:23:21Z
dc.date.available2025-01-15T11:23:21Z
dc.date.issued2021en_US
dc.identifier.citationKececiler-Emir, C., Ilhan-Ayisigi, E., Celen-Erden, C., Nalbantsoy, A., & Yesil-Celiktas, O. (2021). Synthesis of resveratrol loaded hybrid silica-PAMAM dendrimer nanoparticles with emphases on inducible nitric oxide synthase and cytotoxicity. Plant Foods for Human Nutrition, 76(2), 219-225.en_US
dc.identifier.issn09219668
dc.identifier.urihttps://10.1007/s11130-021-00897-5
dc.identifier.urihttps://hdl.handle.net/20.500.12513/7043
dc.description.abstractResveratrol is a naturally occurring polyphenolic compound exhibiting therapeutic activities. However, the stability can be altered by UV light, pH and changes in temperature. Encapsulation would be an ideal strategy to improve the stability and bioavailability. Thus, trans-resveratrol (Res) was encapsulated within hybrid nanoparticles consisted with silica and G4 polyamidoamine dendrimer (PAMAM) by sol-gel method. The diameters of synthesized nanoparticles (NPs) were at a range of 212–574 nm and the encapsulation efficiency was 86 %. RAW 264.7 murine macrophage cell line induced with endotoxin/lipopolysaccharide was treated with free resveratrol and Res-loaded NPs for assessing inhibition of inducible nitric oxide synthase (iNOS), where IC50 values of free resveratrol and Res-loaded NPs were 122.68 µM and 249.74 µM. As for cytotoxicity, IC50 values of free resveratrol were found as 176.57 µM and 201.54 µM for MCF-7 and MDA-MB-231 cells, whereas 197.16 µM and 219.07 µM for Res-loaded NPs for the respective cell lines. Overall, sol-gel technique proved to be an ideal technology as can be carried out under mild conditions and Res-loaded NPs have potential to be utilized in the industry. © 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.en_US
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.relation.isversionof10.1007/s11130-021-00897-5en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCytotoxicityen_US
dc.subjectİNOSen_US
dc.subjectNanoparticleen_US
dc.subjectPAMAMen_US
dc.subjectResveratrolen_US
dc.subjectSol‐gelen_US
dc.titleSynthesis of Resveratrol Loaded Hybrid Silica-PAMAM Dendrimer Nanoparticles with Emphases on Inducible Nitric Oxide Synthase And Cytotoxicityen_US
dc.typearticleen_US
dc.relation.journalPlant Foods for Human Nutritionen_US
dc.contributor.departmentMühendislik-Mimarlık Fakültesien_US
dc.contributor.authorIDEsra İlhan Ayışığı / 0000-0003-1880-4261en_US
dc.identifier.volume76en_US
dc.identifier.issue2en_US
dc.identifier.startpage219en_US
dc.identifier.endpage225en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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