• Rat brain and testicular tissue effects of radiofrequency radiation exposure: Histopathological, DNA damage of brain and qRT-PCR analysis 

  Yavaş, Mehmet Cihan; Kilitçi, A.; Çelik, Ekin; Yegin, K.; Sirav, B.; Varol, S. (Novin Medical Radiation Institute, 2024)

  Background: The Background: We evaluate the effects of radiofrequency electromagnetic field (RF-EMF) on rat brain and testicular tissue using histopathology, comet assay, and real-time quantitative PCR techniques. Materials ...

• Isolation, characterization, and genetic diversity of Paenibacillus larvae from AFB suspected specimens in the Central and Eastern Black Sea Regions 

  Alpay Karaoğlu, Şengül; Bozdeveci, Arif; Pınarbaş Çetin, Müberra; Sevim, Elif; Suyabatmaz, Şeyma (Springer Science and Business Media Deutschland GmbH, 2023)

  American foulbrood is an important bacterial disease affecting the larvae of honey bees (Apis mellifera L.) caused by Paenibacillus larvae. Due to easy transmission of disease and the ability of bacteria to create spores, ...

• GO containing PHBHX bone scaffold: GO concentration and in vitro osteointegration 

  Arslan, Arslan Kağan; Çelik, Ekin; Alkan, Funda; Demirbilek, Murat (Springer Science and Business Media Deutschland GmbH, 2022)

  Trauma, congenital abnormalities or cancer-induced bone defects can be treated with tissue engineering products. Graphene oxide-containing polymeric scaffolds are used as an artificial extracellular matrix, acting as an ...

• Increased serum myonectin and irisin levels with myonectin and FNDC5 expressions in polycystic ovary syndrome: a case control study 

  Onat, Taylan; Inandiklioglu, Nihal; Kara, Mustafa; Serdar Yalvac, Ethem; Türkler, Can; Çıplak, Barış; Altındağ, Mehmet Murat (Taylor and Francis Ltd., 2022)

  The aim of this study is to assess the FNDC5 and myonectin expressions and serum levels of myonectin and irisin in women with PCOS. 90 participants were included in this case-control study. 45 of these participants were ...

• Thioredoxin System and miR-21, miR-23a/b and let-7a as Potential Biomarkers for Brain Tumor Progression: Preliminary Case Data 

  Kılıç, Nedret; Boyacıoğlu, Özge; Saltoğlu, Gamze Turna; Bulduk, Erkut Baha; Kurt, Gökhan; Korkusuz, Petek (Elsevier Inc., 2022)

  Background: The thioredoxin system and microRNAs (miRNAs) are potential targets for both cancer progression and treatment. However, the role of miRNAs and their relation with the expression profile of thioredoxin system ...

• Dual delivery of platelet-derived growth factor and bone morphogenetic factor-6 on titanium surface to enhance the early period of implant osseointegration 

  Keçeli, H. Gencay; Bayram, Cem; Çelik, Ekin; Ercan, Nuray; Demirbilek, Murat; Nohutçu, Rahime Meral (Blackwell Munksgaard, 2020)

  Objective: To test the surface properties and in vitro effects of a new sequential release system on MC3T3-E1 cells for improved osseointegration. Background: BMP6-loaded anodized titanium coated with PDGF containing silk ...

• A study on bone tissue engineering: Injectable chitosan-g-stearic acid putty 

  Yalman, Volkan; Çelik, Ekin; Arslan, Ömer; Alkan, Funda; Türkolu, Nelisa Laçin; Hirin, Hasret Tolga; Arslan, Arslan Kaan; Demirbilek, Murat (IOS Press, 2020)

  Bioengineering products can help bone tissue regeneration. OBJECTIVE: There is an ongoing research for more effective biomaterials in bone regeneration. Chitosan (Ch) grafted stearic acid (Ch-g-Sa) polymer was synthesized ...

• Does long-term talc exposure have a carcinogenic effect the female genital system of rats? An experimental pilot study 

  Keskm, Nadi; Teksen, Yasemin Aktan; Ongun, Esra Guerlek; Oezay, Yusuf; Saygili, Halil (SPRINGER HEIDELBERG, 2009)

  Objective In several studies, the prolonged exposure to talc has been associated with development of ovarian cancer. However, some studies have advocated contrary views. The present study aims to investigate histopathological ...

• Angiotensin converting enzyme gene insertion/deletion variant and familial Mediterranean fever-related amyloidosis 

  Nursal A.F.; Turkmen E.; Kaya S.U.; Tekcan A.; Sezer O.; Celik S.D.; Yigit S. (Iranian Society of Nephrology, 2018)

  Introduction. The most important complication of familial Mediterranean fever (FMF) is secondary amyloidosis, which can lead to kidney failure. Genetic variability in the genes of various components of the renin-angiotensin ...

• Impact of glucocorticoid receptor gene Bcl-1 variant on temporomandibular disorders 

  Tumer M.K.; Yerliyurt K.; Nursal A.; Karakus N.; Tekcan A.; Yigit S. (Scientific Publishers of India, 2017)

  Objectives: Temporomandibular Disorders (TMD) constitute a heterogeneous group of disorders characterized by alterations in mandibular movement. The aim of this study was to investigate the association between the Bcl1 ...

• Angiotensin converting enzyme and methylenetetrahydrofolate reductase gene variations in fibromyalgia syndrome 

  Inanir, Ahmet; Yigit, Serbulent; Tekcan, Akin; Pinarli, Ferda Alpaslan; Inanir, Sema; Karakus, Nevin (ELSEVIER, 2015)

  Objective: Fibromyalgia syndrome (FM) is a common disease characterized by generalized body pain, sensitivity in certain physical areas (sensitive points), lowered pain threshold, sleep disorder, and fatigue. The study ...

• Relationship between major depressive disorder and ACE gene I/D polymorphism in a Turkish population 

  Inanir, Sema; Yigit, Serbulent; Celikel, Feryal Cam; Ates, Omer; Taycan, Serap Erdogan; Nursal, Ayse Feyda; Tekcan, Akin (UNIV SAO PAULO, INST PSIQUIATRIA, 2016)

  Background: Major depressive disorder (MDD) is a complex disease and a significant health problem that is prevalent across the world. Angiotensin-converting enzyme (ACE) has an important role in renin-angiotensin system ...

• Genotoxic Effects of Prenatal Exposure to Levetiracetam During Pregnancy on Rat Offsprings 

  Tural, Sengul; Tekcan, Akin; Elbistan, Mehmet; Karakus, Nevin; Ozyurek, Hamit; Kara, Nurten (INT INST ANTICANCER RESEARCH, 2015)

  Levetiracetam is a new-generation antiepileptic drug initially approved as an adjunctive treatment for patients with refractory partial seizures and is now also used as a monotherapy. The aim of this study was to evaluate ...

• Effects of subtelomeric copy number variations in miscarriages 

  Tekcan, Akin; Elbistan, Mehmet; Tural, Sengul; Cetinkaya, Mehmet Bilge (TAYLOR & FRANCIS LTD, 2015)

  Purpose: This study was performed on miscarriage samples for chromosome analysis to detect copy number variations (CNVs) related to subtelomeric regions, and with these results we aimed to adapt multiplex ligation-dependent ...

• Mutational Spectrum of the MEFV Gene in AA Amyloidosis Associated With Familial Mediterranean Fever 

  Nursal, Ayse Feyda; Tekcan, Akin; Kaya, Suheyla Uzun; Turkmen, Ercan; Yigit, Serbulent (IRANIAN SOC NEPHROLGY, 2016)

  Introduction. Familial Mediterranean fever (FMF) is a recessively inherited disease which is characterized by recurrent episodic fever, abdominal pain, and polyserositis. It is caused by mutations in the MEFV gene, encoding ...

• The Effect of IL-4 Gene Polymorphism in Carpal Tunnel Syndrome 

  Tekcan, Akin; Cevik, Betul; Inanir, Ahmet; Yigit, Serbulent (DERMAN MEDICAL PUBL, 2016)

  Aim: Carpal tunnel syndrome (CTS) is a neurological disorder characterized by paresthesia and pain in the hands due to lesions and /or dysfunction of the median nerve at the wrist. The exact pathogenesis of CTS is not ...

• Investigation of CD40 gene rs4810485 and rs1883832 mutations in patients with recurrent aphthous stomatitis 

  Yigit, Serbulent; Tekcan, Akin; Rustemoglu, Aydin; Tumer, Mehmet Kemal; Kalkan, Goknur; Yerliyurt, Kaan (PERGAMON-ELSEVIER SCIENCE LTD, 2017)

  Objectives: Recurrent aphthous stomatitis (RAS) is a common painful disorder affecting oral health, mucosa and overall quality of life. The etiopathogenesis of RAS remains unclear. RAS shows a large genetic diversity among ...

• Evaluation of apoptotic cell death on liver and kidney tissues following administration of levetiracetam during prenatal period 

  Tekcan, Akin; Tural, Sengul; Elbistan, Mehmet; Guvenc, Tolga; Ayas, Bulent; Kara, Nurten (TAYLOR & FRANCIS LTD, 2017)

  Objective: Levetiracetam is a new generation antiepileptic drug used in treatment of patients with epilepsy and has adverse effects on different tissues. We aimed to evaluate the apoptotic effects of levetiracetam exposure ...

• Evaluation of MIF-173 G/C Polymorphism in Turkish Patients with Ankylosing Spondylitis 

  Gurel, Cevik; Inanir, Ahmet; Nural, Ayse Feyda; Tekcan, Akin; Rustemoglu, Aydin; Yigit, Serbulent (GALENOS YAYINCILIK, 2016)

  Background: Ankylosing spondylitis (AS) is a chronic inflammatory disease mainly affecting the spine and sacroiliac joints. Macrophage migration inhibitory (MIF) factor is a regulatory cytokine that inhibits random immune ...

• In Silico Analysis of FMR1 Gene Missense SNPs 

  Tekcan, Akin (HUMANA PRESS INC, 2016)

  The FMR1 gene, a member of the fragile X-related gene family, is responsible for fragile X syndrome (FXS). Missense single-nucleotide polymorphisms (SNPs) are responsible for many complex diseases. The effect of FMR1 gene ...

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