Kırşehir Ahi Evran Üniversitesi Kurumsal Akademik Arşivi
DSpace@Kırşehir, Kırşehir Ahi Evran Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve yayınların etkisimi artırmak için telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
An İnsight İnto PANI-Tio2 Photocatalysis of Refractory Organic Matter Through Molecular Size Fractionation
(Springer, 2024) Uyguner-Demirel, Ceyda Senem; Türkten, Nazlı; Bekbolet, Miray
Refractory organic matter (RfOM) is ubiquitous in aquatic environment and plays various roles in regulating the fate, transport, toxicity, and bioavailability of chemical species, such as metals, emerging organic contaminants, and nanomaterials. RfOM is mainly represented by humic acids (HA) as the acid insoluble fraction of organic matrix. Considering the complex and multicomponent characteristic of HA, a detailed study was designed to elucidate the fate of molecular size fractions (MSFrs) of humic under solar irradiation in the presence of polyaniline (PANI)-modified TiO2 composites. Humic acid as a consortium of diverse molecular size fractions with different tendencies towards oxidation requires further assessment by UV–vis and fluorescence spectroscopic parameters complementary to previous studies on the photocatalytic degradation of RfOM by using TiO2 and PANI-TiO2 composites. Absorbance-based removal efficiencies under initial and post-photocatalytic conditions showed a re-formation trend during photocatalysis in the presence of PANI and TiO2 where higher MSFrs were transformed to lower MSFrs that was apparent for < 3 kDa fraction. Completely different profiles were observed for PT-41 and PT-81 indicating similar degradation pathways independent of PANI ratio in the composite. As confirmed by the investigated parameters, formation of both 450 kDa and 220 kDa MSFrs were evident under all conditions indicating in situ generation of higher MSFrs. The eligibility of coupled absorbance-fluorescence measurements to discern molecular size distribution of humic acid via oxidative degradation was also investigated. Excitation-emission matrix (EEM) contour plots emphasized the ratio dependency of PANI modification of TiO2 and revealed sample specific variations that were more pronounced in terms of the emergence of tyrosine- and tryptophan-like aromatic proteins.
The Association Between Respiratory Functions, Pain Tolerance and Body Awareness in Obstructive Lung Diseases
(W.B. Saunders, 2025) Vardar-Yağlı, Naciye; Sağlam, Melda; Fırat, Merve; İnal-İnce, Deniz; Çalık-Kutukçu, Ebru; ...; Çöplü, Lutfi
Purpose: There are only a limited number of studies in the literature evaluating body awareness, pain perception, and the relationship between clinical parameters and respiratory functions in patients with obstructive lung disease (OLD) and compared with healthy individuals. Therefore, this study aimed to evaluate respiratory functions, pain tolerance, and body awareness in patients with OLD and compare these findings with those of healthy individuals. Methods: The study included 33 patients and 30 healthy individuals. The respiratory function (spirometer), respiratory muscle strength (mouth pressure device), endurance (threshold loading device), pain level and tolerance (short-form McGill Pain Questionnaire and algometer), posture, and body awareness (Body Awareness Questionnaire-BAQ) were evaluated. Results: The pain threshold and tolerance of the biceps, triceps, trapezius, and quadriceps muscles were significantly lower and BAQ scores were higher in patients with OLD compared with healthy individuals (p < .05). There was a significant relationship between FEV1 (%) and pain tolerance of the triceps (r = 0.371, p = .047) and gastrocnemius muscles (r = 0.419, p = .024); FVC (%) and pain threshold of the gastrocnemius (r = 0.413, p = .023), triceps muscles (r = 0.394, p = .034), and pain tolerance of the gastrocnemius muscle (r = 0.549, p = .002). Conclusions: Patients with OLD have a marked increase in pain perception and body awareness levels and a decrease in pain threshold and tolerance compared with healthy controls. Future studies should assess the effectiveness of pain management interventions as a part of pulmonary rehabilitation for patients with chronic respiratory diseases. Clinical Implications: Pain management is important for planning pulmonary rehabilitation programmes.
Investigation of Weldability in Friction Stir Welding of Aluminum Alloys AA5754 and AA2024
(Springer, 2025) Kılıç, Süleyman; Öztürk, Fahrettin; Demirdöğen, Mehmet Fatih
Abstract
This study examined the weldability of AA5754 and AA2024 aluminum alloys using the friction stir welding (FSW). Through systematic analysis of welding parameters such as rotational and traverse speeds, we have identified configurations to improve the mechanical properties and efficiency of the welds significantly. The optimal parameters, specifically a rotational speed of 1200 rpm combined with a traverse speed of 45 mm/min, were found to yield the best outcomes. The welding efficiency achieved was 54% for the AA5754 alloy and 26% for the AA2024 alloy, with a combined alloy efficiency of 47% when welding dissimilar materials. The study has conclusively demonstrated that appropriate parameter selection is crucial for maximizing weld strength and minimizing defects such as voids and cracks. This research contributes to the understanding of the FSW applicability in joining dissimilar aluminum alloys, emphasizing the importance of parameter optimization to achieve desirable mechanical characteristics and weld integrity.
Effects of Early Mobilization in Elderly Patients Undergoing Cardiac Surgery
(Springer Science and Business Media Deutschland GmbH, 2024) Ceylan, İsmail; Mhmood, Azhar Hassan; Al-Janabi, Raed Qadri Khudhair
Background: Although early mobilization is associated with improved outcomes in postoperative cardiac patients, implementation of early mobilization in elderly patients is still a challenge. Aims: In this study, we aimed to design and assess an early mobilization program for cardiac rehabilitation. Methods: We conducted a clinical trial in elderly patients aged over 65 years after coronary artery bypass graft surgery. Patients were randomly assigned to an early mobilization group (Group A) or a routine therapy group (Group B). Short-Form International Physical Activity Questionnaire (SF-IPAQ), to assessment balance Time Up and Go (TUG), to assessment functional capacity the 2-min walking test (2MWT) and the short physical performance battery (SPPB) were used as a reference to formulate and monitor the early mobilization regimen. Results: A total of 100 patients were enrolled (n = 50 per group). The mean walking distance in Group A was significantly higher at 135.6 ± 9.29 than the mean walking distance in Group B which was lower at 123.4 ± 8.48. Also, the patients in Group B had a mean SF-IPAQ of 389.44 with an SD of 85.7, P < 0.001, whereas the mean SF-IPAQ amount in Group A was 556.16 with an SD of 91.47. In early mobilization group, a strong positive connection was indicated by the correlation coefficient of r = 0.957 between the amount of SF-IPAQ and 2 MWT and there was a significant negative association r = − 0.768 between 2MWT and TUG. Conclusion: Our study’s findings suggest that early mobilization and functional exercises enhanced balance, functionality, and life quality for older cardiac patients.
Exploring the Potential of Isoindole-1,3-Dione Derivatives as Novel Inhibitors of Aldose Reductase: An In Silico and In Vitro Insight into Therapeutic Strategies for Diabetic Complications
(John Wiley and Sons Inc, 2024) Şengül, Bülent; Gündoğdu, Özlem; Kılınç, Namık; Kıshalı, Nurhan
This study explores the potential of isoindole-1,3-dione derivatives as novel inhibitors of aldose reductase (AR), focusing on their in silico and in vitro effects for therapeutic strategies against diabetic complications. Aldose reductase, a critical enzyme in the polyol pathway, plays a significant role in glucose metabolism and has been linked to diabetic complications. In this comprehensive study, isoindole-1,3-dione derivatives were synthesized and evaluated for their inhibitory effects on the recombinant human AR enzyme. The compounds’ inhibitory activities were measured both in vitro and through in silico techniques, employing molecular docking and free binding energy calculations and ADME studies. The newly synthesized compounds demonstrated varied inhibitory effects, with ethyl and phenyl substituents at specific positions enhancing inhibitory activity. Notably, compounds with carboxylic acid derivatives exhibited potent inhibitory effects, especially compound 6 with an IC50 value of 1.649 μM. In conclusion, this study provides valuable insights into the inhibitory potential of isoindole-1,3-dione derivatives against AR, suggesting their potential therapeutic application in mitigating diabetic complications. The combination of experimental and computational approaches offers a comprehensive understanding of the compounds’ interaction mechanisms and pharmacokinetic profiles, supporting their further exploration as antidiabetic agents.
