Kırşehir Ahi Evran Üniversitesi Kurumsal Akademik Arşivi
DSpace@Kırşehir, Kırşehir Ahi Evran Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve yayınların etkisimi artırmak için telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Synthesis, Antimicrobial Evaluation, and Molecular Docking Analysis of Novel Schiff Bases Derived from Isatoic Anhydride and Salicylaldehyde
(Multidisciplinary Digital Publishing Institute (MDPI), 2026) Tunç, Turgay; Köse, Yaşar
Schiff bases are bioactive compounds that have been synthesized by many researchers in recent years. They may also exhibit strong antimicrobial activities against various pathogenic microorganisms in both medicine and veterinary applications. The synthesis of new Schiff base-derived compounds remains of interest due to the increasing problem of antibiotic-resistance in clinical practice. Seven new Schiff base derivatives were synthesized, and their chemical structures were characterized using FT-IR, 1H/13C NMR, and LCMS-MS analyses. The antimicrobial activities of thesyntesized compounds against various pathogenic bacteria, yeasts, and fungi were evaluated using the disk-diffusion method, and their MIC values were also determined. In addition, one representative microorganisms from each class were selected for molecular docking studies. IFD analyses were performed for the 4f and 4g ligands using the dihydrofolate reductase enzyme. Spectroscopic analyses confirmed the structures of the synthesized compounds, revealing the presence of characteristic imine functionalities and validating the integrity of the molecular frameworks. Antimicrobial assays demonstrated that several derivatives exhibited measurable activity, with compounds 4f and 4g showing the most potent effects, displaying MIC values of 32 µg/mL against B. cereus and E. faecalis, respectively. Molecular docking studies further indicated that both 4f and 4g bind efficiently to the DHFR active site. These findings indicate that among the synthesized Schiff base derivatives, compounds 4f and 4g exhibit particularly promising antimicrobial activity, warranting further pharmacological evaluation and medicinal chemistry optimization.
Interpreting Linear Enamel Hypoplasia at the Amastris (Ağlayan Ağaç) Chapel Cemetery From the Eastern Roman Imperial Period Region of Paphlagonia (Türkiye)
(John Wiley and Sons Ltd, 2026) Taş, Ali; Şener, Elçin; Erkman, Ahmet Cem
Abstract
The aim of this study is to evaluate the values of linear enamel hypoplasia (LEH) observed in the permanent teeth of individuals excavated from a chapel site dated to the Late Eastern Roman Period (6th–9th centuries) through analytical methods. The study is based on LEH findings identified in 148 (37.4%) of 396 permanent teeth belonging to 30/54 individuals. LEH measurements were conducted using two well-established methodologies documented in the literature. The prevalence of LEH suggests that the onset of the weaning process in infancy or early childhood coincided with the emergence of disease-inducing factors, estimated to occur between the ages of 3.5 and 5 years. Comparative evaluation of the two methodological approaches revealed consistent and convergent findings. It is hypothesized that a combination of factors including metabolic disorders, pathological conditions, environmental influences, socialization patterns, poor hygiene, nutritional deficiencies, and suboptimal living conditions contributed to heightened disease susceptibility during the weaning phase. This study presents the first LEH dataset from the Western Black Sea (Paphlagonia) region of Türkiye and contextualizes the findings through comparisons with other coastal harbor communities previously examined in a limited capacity. This research focuses on a comprehensive analysis to help create a more chronological and geographical comprehensive LEH dataset of ancient Anatolian societies in later periods.
Energy Use Efficiency and Greenhouse Gas Emissions in Sour Cherry (Prunus cerasus L.) Production Systems in Türkiye
(Springer Science and Business Media Deutschland GmbH, 2026) Candemir, Serhan; Bozdemir Akçil, Merve; Doğan, Hasan Gökhan; Bayramoğlu, Zeki
[Not Abstract Available]
Energy Use Efficiency and Greenhouse Gas Emissions in Plum (Prunus domestica L.) Production: Evidence from Central Türkiye
(Springer Science and Business Media Deutschland GmbH, 2026) Bozdemir Akçil, Merve; Candemir, Serhan; Doğan, Hasan Gökhan; Bayramoğlu, Zeki
This research sought to study the amount of energy and the amount of greenhouse gas released in the plum growing in Akşehir, a district of Konya. The information was obtained from the farmers mentioned above, by means of questionnaires which were filled up during a part of the 2025 harvest. In order to ascertain the energy and emission values of all inputs, standard references available to workers in agricultural investigations were used. Total energy input was found to be 10,441.48 megajoules per hectare, while total energy output was 26,127.53 megajoules per hectare. This means that for one unit of energy put in, there is about 2.53 units received. Nearly one half of all energy used is in the form of electricity, which also has the greatest potential effect on the general appearance of the farm from the point of view of its energy economy. The total amount of greenhouse gases evolved was estimated to be about 1217 kg per hectare, in terms of equivalent CO, of which about three-fourths come from the use of electric energy. These results show that there is an efficient use of energy in the growing of plums in this region, but that it is rather limited in its possibilities for improvement in environmental quality on account of the rare use of renewable energy. The greatest possibilities for use of this renewable energy lies in the way of increased use of solar energy for irrigation and from the use of machinery that is more economical in energy used for that purpose. The general effect of this would be a decrease in cost of production which would mean greater opportunity for agricultural enterprise and at the same time an improved quality of the farm from the point of view of it being more happily located in a less polluted environment.
Energy Use and Emission Efficiency in White Cherry Production: Evidence from Türkiye
(Springer Science and Business Media Deutschland GmbH, 2026) Bozdemir Akçil, Merve; Candemir, Serhan; Doğan, Hasan Gökhan; Bayramoğlu, Zeki
[Not Abstract Available]
