Kırşehir Ahi Evran Üniversitesi Kurumsal Akademik Arşivi
DSpace@Kırşehir, Kırşehir Ahi Evran Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve yayınların etkisimi artırmak için telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Exploring the Potential of Isoindole-1,3-Dione Derivatives as Novel Inhibitors of Aldose Reductase: An In Silico and In Vitro Insight into Therapeutic Strategies for Diabetic Complications
(John Wiley and Sons Inc, 2024) Şengül, Bülent; Gündoğdu, Özlem; Kılınç, Namık; Kıshalı, Nurhan
This study explores the potential of isoindole-1,3-dione derivatives as novel inhibitors of aldose reductase (AR), focusing on their in silico and in vitro effects for therapeutic strategies against diabetic complications. Aldose reductase, a critical enzyme in the polyol pathway, plays a significant role in glucose metabolism and has been linked to diabetic complications. In this comprehensive study, isoindole-1,3-dione derivatives were synthesized and evaluated for their inhibitory effects on the recombinant human AR enzyme. The compounds’ inhibitory activities were measured both in vitro and through in silico techniques, employing molecular docking and free binding energy calculations and ADME studies. The newly synthesized compounds demonstrated varied inhibitory effects, with ethyl and phenyl substituents at specific positions enhancing inhibitory activity. Notably, compounds with carboxylic acid derivatives exhibited potent inhibitory effects, especially compound 6 with an IC50 value of 1.649 μM. In conclusion, this study provides valuable insights into the inhibitory potential of isoindole-1,3-dione derivatives against AR, suggesting their potential therapeutic application in mitigating diabetic complications. The combination of experimental and computational approaches offers a comprehensive understanding of the compounds’ interaction mechanisms and pharmacokinetic profiles, supporting their further exploration as antidiabetic agents.
Seeing the Whole Picture: Exploring the Predictors of Preschool Teachers' İntentions Toward Child-Centred Approach from A Socio-Psychological Perspective
(Elsevier Ltd, 2024) Dilek, Hasan
This study was aimed to explore the determinants influencing teachers' intentions towards child-centred approach within an overarching model. An analytical process incorporating a structural equation model and multiple-indicators-multiple-cases procedure indicated that attitudes do not significantly impact teachers' intentions and indicated that external factors, such as social pressures play a more substantial role in shaping their intentions. Moreover, personal and situational factors affect teachers’ self-efficacy and intentions. This study enriches the existing literature by illuminating the significance of social pressure and self-efficacy in shaping teachers' intentions towards child-centred approach. These findings bear critical implications for school directors, policymakers, and professional development programs.
Improved Generalized Differential Transform Method for A Class of Linear Nonhomogeneous Ordinary Fractional Differential Equations
(Bentham Science Publishers, 2023) Kıymaz, Onur; Çetinkaya, Aysegül
In this paper, by using the generalized Taylor's formula we improved the generalized differential transform method, which is a useful tool for getting the approximate analytic solutions of fractional differential equations. With this improvement, solutions of a class of linear nonhomogeneous ordinary fractional differential equations, which could not be solved with generalized differential transform method before, will be achieved and the solutions obtained will contain more integers and fractional exponents.
Efforts to Raise Social Awareness Against Cholera During the Second Constitutional Years (1908-1914)
(Istanbul University Press, 2024) Akagündüz, Ümüt
This study evaluates the measures against cholera based on the epidemics experienced in the Second Constitutional years. In the 19th century, cholera, which caused numerous deaths worldwide due to industrialization and poor urbanization, also affected the Ottoman Empire. The fear caused by cholera led to transformations in health policies and municipal services. Cholera, which also impacted the Second Constitutional Period, spread throughout the country, especially in Istanbul, between 1909 and 1913. The cholera epidemics, coupled with domestic and foreign political chaos, were frequently emphasized in the publications of the time. Periodicals, books, parliamentary debates, and state archives from the period provide much information on the epidemic. These data illuminate the nature of the disease and the struggles against it, embodying scientific, pragmatic, and popular methods of information dissemination. This article employs survey models and document analysis, utilizing literature that focuses on the local and global course of cholera, as well as archive documents, periodicals, books, and memorandums that clarify the period’s conditions. The data from the press and publication life reveal that, in addition to health policies, public awareness was also significant in the fight against cholera.
Novel Α-N-Heterocyclic Thiosemicarbazone Complexes: Synthesis, Characterization, and Antimicrobial of Properties İnvestigation
(Royal Society of Chemistry, 2024) Nartop, Dilek; Hasanoğlu Özkan, Elvan; Öğütçü, Hatice; Kurnaz Yetim, Nurdan; Özdemir, İnci
In this paper, eight novel α-N-heterocyclic thiosemicarbazone complexes were synthesized in search of new biologically active compounds, and characterized via organic elemental analysis, nuclear magnetic resonance spectroscopy, infrared spectra, thermogravimetric analysis, ultraviolet-visible spectroscopy, molar conductance and magnetic susceptibility measurements. The in vitro antimicrobial activity of these complexes was examined against ten disease-causing pathogens: Gram-positive bacteria (Micrococcus luteus ATCC9341, Staphylococcus epidermidis ATCC12228, Bacillus cereus RSKK863) and Gram-negative bacteria (Pseudomonas aeroginosa ATCC27853, Klebsiella pneumonia ATCC27853, Enterobacter aerogenes ATCC51342, Salmonella typhi H NCTC9018394, Shigella dysenteria NCTC2966, Proteus vulgaris RSKK96026) and yeast (Candida albicans Y-1200-NIH). The results revealed that the α-N-heterocyclic thiosemicarbazone compounds showed potent activity. It was observed that all thiosemicarbazone complexes were more susceptible to Gram-negative strains based on the presence of an electron-withdrawing substituent (-Br/-Cl/-F). It was determined that thiosemicarbazone Cu2+complexes showed stronger antifungal effects.
