Kırşehir Ahi Evran Üniversitesi Kurumsal Akademik Arşivi
DSpace@Kırşehir, Kırşehir Ahi Evran Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve yayınların etkisimi artırmak için telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Design, Development, and Clinical Validation of a Novel Kit for Cell-Free DNA Extraction
(Multidisciplinary Digital Publishing Institute, 2025) Çelik, Ekin; Güner, Hande; Kayalı, Gizem; Erdem, Haktan Bağış; Bahsi, Taha; Kazan, Hasan Hüseyin
[Not Abstract Available]
Deciphering Molecular Overlaps between COPD and NSCLC Subtypes (LUAD and LUSC): An İntegrative Bioinformatics Study
(Lippincott Williams and Wilkins, 2025) Akçay, Sevinç
Chronic obstructive pulmonary disease (COPD) and non-small-cell lung cancer (NSCLC) are major global health problems. Despite clinical differences, emerging evidence suggests common molecular underpinnings, particularly between COPD and the 2 primary NSCLC subtypes, lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). In this integrative bioinformatics case-control study, we analyzed gene expression datasets (GSE76925, GSE18842, and GSE10072) obtained from the Gene Expression Omnibus (GEO) database, each comprising case-control samples. Differentially expressed genes (DEGs) were identified in COPD, LUAD, and LUSC patients. We performed analyses of protein-protein interaction (PPI) networks, investigated regulatory networks involving transcription factors (TFs) and microRNAs (miRNAs), and conducted pathway enrichment analysis using Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) databases. Drug-gene interactions were assessed to explore therapeutic opportunities. We identified 15 shared DEGs between COPD, LUAD, and LUSC, with distinct gene expression patterns between COPD-LUAD and COPD-LUSC. Notably, LUAD exhibited stronger molecular similarities with COPD than with LUSC. PPI analysis revealed COL10A1, POSTN, SPP1, MMP11, and GREM1 as key hub genes in extracellular matrix (ECM) remodeling and tumor progression. Functional enrichment highlighted ECM organization, apoptosis regulation, and transcriptional control as crucial processes in COPD-associated NSCLC. COPD-LUAD was enriched in cancer-related pathways, while COPD-LUSCs showed stronger immune and lipid metabolism involvement. Regulatory network analysis identified SP1 as a key transcriptional regulator, particularly in COPD-LUAD cells. miRNA-DEG interactions highlighted "hsa-miR-335-5p,""hsa-miR-192-5p,"and "hsa-miR-215-5p"as the central regulators of COPD and NSCLC. Drug-gene interaction analysis identified Marimastat, Bosentan, and Minocycline as potential therapeutic agents that target key molecular pathways shared across COPD, LUAD and LUSC. Finally, survival analysis revealed that SPP1 (in LUAD), POSTN, and GREM1 (in LUSC) were significantly associated with better overall survival, suggesting their dual utility as both biomarkers and prognostic indicators. Our research highlights the unique regulatory distinctions between LUAD and LUSC while offering fresh insights into the molecular pathways that COPD and NSCLC share. This study represents the initial effort to map TF-miRNA-DEG-drug networks across COPD and both the LUAD and LUSC subtypes. These results suggest potential biomarkers for early diagnosis and highlight opportunities for drug repurposing to mitigate COPD-associated lung cancer risk.
The Analysis of Producers' Technology İnvestment İntentions Within the Framework of Extended Theory of Planned Behavior
(Elsevier B.V., 2025) Mirza, Emel; Bayramoğlu, Zeki; Doğan, Hasan Gökhan; Candemir, Serhan; Ganiyusufoğlu, Ali; Edirneligil, Ayşen
This study is based on the Theory of Planned Behavior and expands this main framework by including the constructs of education, knowledge acquisition and access to financial resources. In this study conducted on 270 farmers in Konya -an important agricultural region of Turkey-, a stratified sampling design was employed with a survey instrument adapted from previously validated measurements. Robust reliability and validity were confirmed for constructs related to attitude, subjective norms, perceived behavioral control, knowledge acquisition and access to financial resources through Partial Least Squares Structural Equation Modeling approach. The results obtained show that attitude, subjective norms and knowledge acquisition significantly increase the perceived behavioral control of farmers. On the other hand, there is an indirect relationship between perceived behavioral control and technology investment intention through the access to finance, which indicates that access to financial resources emerges as a pivotal factor determining technological investment intentions. These results imply that it is important to improve the farmers' financial capacity and information support to promote technology adoption. In this context, policy makers and agencies working in the field of agricultural development need to spearhead the process of the financial barriers and knowledge resources, by first selecting credit facilities, providing government subsidies and later knowledge transfer.
Recovery of molybdenum, cobalt and nickel from spent hydrodesulphurization catalyst through oxidizing roast followed by sodium persulfate leaching
(ELSEVIER, jul 2021) Arslanoğlu, Hasan; Yaras, Ali
The spent hydrodesulphurization (HDS) catalyst is an important secondary source for Ni, Mo, Co and Al metals. The high yield recovery of these metals is quite difficult due to the carbon accumulated on the catalyst surface and the stability of the metal oxides. Therefore, the leaching process in the presence of sodium persulfate (Na2S2O8) was carried out after the roasting pre-treatment to remove the carbon from the spent HDS catalyst structure and convert the metal oxides to the soluble form in this study. The optimum experimental conditions were determined as roasting temperature, 500 degrees C; roasting time, 120 min.; particle size, +75-30 mu m; liquid/solid ratio, 12.5 mL/g; Na2S2O8 concentration, 0.4 M; leaching temperature, 50 degrees C; leaching time, 90 min and stirring speed, 400 r/min. Recovery of Mo (89.8%), Co (86.5%) and Ni (81.2%) from leach solution were achieved by precipitation method. The liquid film diffusion control mechanism best represents the proposed leaching process. On the other hand, the magnitude of Ea values (<20 kJ/mol) for Mo, Co, Ni and Al metals indicates that the leaching process is controlled by liquid film diffusion mechanism. (C) 2021 Elsevier B.V. All rights reserved.
Effect of COVID-19 İnfection on The Performance of Elite Adolescent Overhead Athletes
(SAGE Publications Ltd, 2025) Uluğ, Naime; Kodak, Seyde Büşra; Kodak, Muhammed İhsan; Karahan, Zehra Can; Kılıç, Erden
Background: COVID-19 might have a negative impact on sports performance. There are few studies in the literature that assess how the sports performance of adolescent athletes is affected by COVID-19. Objective: This study aimed to compare the sports performance of adolescent overhead athletes who had COVID-19 infection with those who had not. Methods: The study involved adolescent elite overhead athletes from basketball, volleyball, handball, and tennis. Athletes’ performance were assessed using core muscle endurance, hand grip strength, upper extremity functional performance, reaction time and agility performance, and the 3-min step test. Results: Study included 47 adolescent overhead athletes (mean age 15.15 ± 1.51 years). The COVID-19 group showed significantly higher Borg Scale scores and decrease in oxygen saturation levels only after the step test (p = 0.02, p = 0.02, respectively). Additionally, COVID-19 group had lower grip strength in both right and left hands compared to the non-COVID group (p = 0.01, p = 0.05, respectively). No significant association was found between core muscle power and endurance, upper extremity functional performance, reaction time and agility performance (p > 0.05). Conclusions: Our results showed reduced hand grip strength and increased fatigue following COVID-19 infection in adolescent overhead athletes. Time period after COVID-19 infection had a negative correlation with sports performance and core endurance.
