Kırşehir Ahi Evran Üniversitesi Kurumsal Akademik Arşivi
DSpace@Kırşehir, Kırşehir Ahi Evran Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve yayınların etkisimi artırmak için telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Admission Endothelial Activation and Stress Index and Echocardiographic RV-PA Coupling for Early Risk Stratification in Intermediate-Risk Acute Pulmonary Embolism
(Multidisciplinary Digital Publishing Institute (MDPI), 2026) Keleş, Fikret; Yıldırım, Alp; Parmak, Müzeyyen Gizem; Bilgiç, Ahmet Rıdvan; Ateş, Muhammet Salih; Sökmen, Erdoğan
[Abstract Not Available]
Gallic Acid Attenuates Ifosfamide-Induced Gut Microbiota Dysbiosis: A Full-Length 16S rRNA Amplicon Sequencing Study
(Multidisciplinary Digital Publishing Institute (MDPI), 2026) Öztürk, Cihat; Yalçın, Süleyman; Küçükgünay, Sadık; Mehmetzade, Hakan Farzin; Bolacalı, Memiş; Sevim, Elif
Chemotherapy-induced gastrointestinal toxicity represents a major clinical challenge, with accumulating evidence implicating gut microbiota dysbiosis in reduced treatment tolerance. Ifosfamide is a widely used alkylating agent; however, its effects on gut microbial community structure remain incompletely understood. This preclinical study investigated ifosfamide-associated microbiota alterations and evaluated the microbiota-modulating potential of gallic acid as a supportive intervention. Male rats were assigned to control, ifosfamide, gallic acid, and combined ifosfamide + gallic acid groups. Fecal samples were collected longitudinally and analyzed using full-length 16S rRNA gene sequencing for high-resolution taxonomic profiling. At the phylum level, ifosfamide exposure induced a marked decrease in Bacillota accompanied by a significant expansion of Bacteroidota, reflecting a dysbiotic shift associated with intestinal stress. Genus-level analysis revealed substantial reductions in beneficial taxa, including Lactobacillus, Ligilactobacillus, and Blautia, alongside enrichment of stress-adaptive and opportunistic genera such as Romboutsia and Segatella. Species-level profiling demonstrated significant depletion of mucosa-associated lactic acid bacteria, including Lactobacillus johnsonii, Lactobacillus intestinalis, and Ligilactobacillus murinus, following ifosfamide treatment. Conversely, opportunistic taxa such as Romboutsia ilealis and Segatella copri and transient increases in Escherichia coli were observed, consistent with chemotherapy-induced intestinal perturbation. Gallic acid administration partially preserved microbial diversity, attenuated the expansion of opportunistic taxa, and supported recovery of beneficial bacteria, resulting in an intermediate microbial profile under combination treatment. These findings provide preclinical evidence that gallic acid mitigates ifosfamide-associated gut dysbiosis and highlight gut microbiota modulation as a potential adjunctive strategy to improve chemotherapy tolerance. Further translational and clinical investigations are warranted.
The Effects of Dietary Herbal Powders on Growth, Intestinal Physiology and Meat Quality of Quails (Coturnix japonica)
(Multidisciplinary Digital Publishing Institute (MDPI), 2026) Coşkun, İsa; Çayan, Hüseyin; Çayıroğlu, Hayrettin; Boz, Mehmet Akif; Doğan, Emine; Bilginoğlu, Emine
The aim of this study was to determine the effects of supplementing quail diets with 0.5% thyme, sage, mint, and oregano powder on nutritional performance. A total of 400 one-day-old quail chicks, standardized for live weight, were randomly assigned to five treatment groups with four replicates per group (20 chicks per replicate). The groups were allocated to treatments as C—control, T—thyme, S—sage, M—mint, and O—oregano. The experiment lasted for 35 days. Chicks were reared in cages sized 70 × 90 × 60 cm, with a 10 cm layer of wood shavings on the ground. Feed and water were provided ad libitum. At the end of the experiment, live weight gain and lactic acid bacteria (LAB) colonization in ceca were significantly higher in the T (thyme) and O (oregano) groups compared to the C, S and M groups (p < 0.05). Malondialdehyde (MDA) levels in the breast meat were lower in the S, M and O groups compared to the C group. Jejunal villi length was significantly greater in the S and O groups compared to the others (p < 0.05). In the ileum, villi height was higher in the T group than in the other groups (p < 0.05). The villi height/crypt depth ratio in the jejunum was significantly higher in the T and O groups compared to the C group (p < 0.05), whereas in the ileum, this ratio was lower in the S group than in the other groups. Mucin-2 level in the ileum was significantly reduced in the S, M and O groups compared to the C group (p < 0.05) and was similar between T and C. In conclusion, dietary supplementation with vegetative powder of thyme and oregano can be used to improve growth, intestinal villi morphology and LAB colonization in quails. Also, low-dose herbal powder supplementation can be used to suppress MDA formation in the breast meat stored at 4 °C for 3 days
Isolation and Characterization of Antibiotic-Resistant and Biosurfactant-Producing Hydrocarbon-Degrading Bacteria from Industrial Contaminated Soils
(Multidisciplinary Digital Publishing Institute (MDPI), 2026) Karaman, Muhammed Yunus Emre; Öğütcü, Hatice; Alaylar, Burak; Güllüce, Medine
In the current study, soil samples were collected from regions contaminated with industrial waste containing petroleum and its derivatives, including areas around a tire factory in Kırşehir, a chrome factory in Mersin and Kazanlı, and the Karaduvar refinery regions in Mersin, Türkiye. A total of 40 bacteria were isolated from the soil samples. The isolates were identified using molecular methods as well as morphological, physiological, and biochemical tests. Based on the results of 16S rRNA sequence analysis, it was revealed that the isolates belonged to the genera Bacillus, Diaphorobacter, Cupriavidus, Acinetobacter, Massilia, Staphylococcus, and Azospirillum. The antibiotic and heavy metal resistance of the strains were determined. Furthermore, the Drop Collapse method was employed to evaluate the biosurfactant production abilities of the strains, confirming that certain strains possess biosurfactant-producing capabilities. Consequently, distinct bacterial species capable of degrading polyaromatic hydrocarbons, resisting antibiotics and heavy metals, and producing biosurfactants were successfully isolated from contaminated areas in the current study. It is thought that the utilization of species with these properties in bioremediation studies will contribute to the restoration of ecosystem balance.
A rare case of self-inflicted needle injury
(Wolters Kluwer Medknow Publications, 2026) Karacan Erşekerci, Tülay; Örnek, Kemal
[Abstract Not Available]
