Kırşehir Ahi Evran Üniversitesi Kurumsal Akademik Arşivi
DSpace@Kırşehir, Kırşehir Ahi Evran Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve yayınların etkisimi artırmak için telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Changes in Artemin Correlate with Anxiety- and Depression-like Behaviors in a Lipopolysaccharide-Induced Rat Neuroinflammation Model †
(10.3390/biom15081192, 2025) Çalışkan, Hasan; Koçak, Seda
Artemin is a neurotrophic factor that belongs to the four-member family of Glial-derived growth factors. This study aims to investigate changes in artemin correlated with anxiety and depression-like behaviors in a neuroinflammation rodent model. In adult male Wistar rats, neuroinflammation was established through administration of 2 mg/kg LPS. Anxiety-like behaviors and locomotor activity were evaluated by the open field test. The sucrose preference test and the splash test analyzed depression-like behaviors. Tumor necrosis factor alpha (TNF-α), interleukin-1 beta (IL-1β), and artemin levels were measured in the prefrontal cortex, striatum, and serum. In the neuroinflammation group, rearing, total distance traveled, time spent in the central region, and sucrose solution consumption decreased in the open-field test (p < 0.0001). Grooming time and frequency were shortened, and grooming latency was prolonged in the neuroinflammation group (p < 0.0001). TNF-α was significantly increased in the prefrontal cortex (p < 0.05) and striatum (p < 0.01). lL-1β did not change between groups (p > 0.05). Artemin levels decreased in the prefrontal cortex and striatum (p < 0.05). No difference was observed in serum artemin levels; however, artemin levels of brain regions were higher than those in the serum. An increase in anxiety–depression-like behaviors has accompanied decreased levels of artemin in the brain. Artemin may be a target molecule in psychiatric disorders. Further studies are needed to examine the role of artemin in neuropsychiatric disorders.
Predicting Soil Fertility in Semi-Arid Agroecosystems Using Interpretable Machine Learning Models: A Sustainable Approach for Data-Sparse Regions
(Multidisciplinary Digital Publishing Institute (MDPI), 2025) Acir, Nurullah
[Not Abstract Available]
Speeding Up or Slowing Down: The Effect of Decoupling Speed on Knee Biomechanics and Limb Loading During Split-Belt Treadmill Training in Persons With ACL Reconstruction
(SAGE Publications Inc., 2025) Johnson, Alexa K.; Recchia, Reagan; Tayfur, Abdulhamit; Krishnan, Chandramouli; Palmieri-Smith, Riann M.
Background: Surgical limb underloading is a common biomechanical adaptation after anterior cruciate ligament reconstruction (ACLR) and has been linked to early degenerative changes in knee cartilage, which are considered precursors to posttraumatic osteoarthritis. Split-belt treadmill training is an emerging rehabilitation approach that modifies load through asymmetric gait behavior, in which one limb walks faster than the other. While previous research has indicated that split-belt treadmill training can modify limb loading, its effects on post-ACLR biomechanics remain unexplored. Purpose/Hypothesis: The purpose of this study was to examine the effects of decoupling speed on knee biomechanics and limb loading and model their relationship. It was hypothesized that at faster decoupling speeds, knee loads would increase, and at slower speeds, they would decrease. Study Design: Controlled laboratory study. Methods: Knee joint biomechanics were evaluated while 24 participants (15 females; mean age, 23.5 ± 6.5 years; mean height, 1.72 ± 0.08 m; mean mass, 75.61 ± 13.83 kg; mean postoperative time, 7.94 ± 1.74 months) with ACLR walked on an instrumented treadmill (2000 Hz) synced with a 12-camera motion capture system (200 Hz). Participants completed 5 minutes of baseline walking at 1.1 m/s on tied treadmill belts. Afterward, the authors manipulated the speed of the belt under the ACL-reconstructed leg with 8 randomized 5-minute decoupled speed configurations (ACL-reconstructed limb at 30%-170% of 1.1 m/s in 20% increments) with 2 minutes of tied-belt walking between each speed. Bilateral sagittal plane knee moments, angles, and vertical ground-reaction forces were calculated. Statistical parametric mapping was used to evaluate the effects of decoupling speed on the dependent variables during the stance phase of the gait. Results: A clear dose-response relationship between decoupling speed and knee/limb loading was found. Specifically, faster decoupling speeds (130%-170% of 1.1m/s) generally increased peak loads and slower speeds (30% and 50% of 1.1 m/s) decreased peak loads during early stance compared with tied-belt walking for both limbs. In contrast, slower decoupling speeds (30%-90% of 1.1 m/s) led to higher bilateral knee/limb loads at midstance, while faster decoupling speeds (130%-170% of 1.1 m/s) resulted in less knee/limb loading during midstance. Conclusion: These findings suggest that split-belt treadmill training offers a promising method for modulating knee/limb loading post-ACLR. Clinical Relevance: Split-belt treadmill training could be a viable intervention to target the loading asymmetry that is prevalent in persons post-ACLR.
Jigsaw Puzzle Inspired Patterning of Gas Diffusion Layers for Enhanced Water Management in Polymer Electrolyte Fuel Cells
(John Wiley and Sons Inc, 2025) Can, Enes Muhammet; Nishihara, Masamichi; Sasaki, Kazunari; Lyth, Stephen Matthew
Under high current density operation, water generation at the cathode of polymer electrolyte fuel cells (PEFCs) floods the electrode, resulting in severe mass transport limitation and an associated voltage drop. Water management is thus of crucial importance in improving the overall performance of fuel cell systems. Gas diffusion layers (GDLs) with independent pathways for either gaseous oxygen or liquid water transport present a potential solution to this issue. Here a novel, simple, and scalable method is presented for inducing patterned hydrophobicity into GDLs. Hydrophilic GDLs are prepared by immersion of commercial hydrophobic GDLs in hydrogen peroxide. Circular disks are then punched from these using a precision die-cutter. Meanwhile, an array of corresponding holes is punched into conventional hydrophobic GDLs. The hydrophilic disks are then pressed into the holes of the hydrophobic GDL and held in place via friction locking, analogous to completing a jigsaw puzzle. This Jigsaw Puzzle Inspired Patterning (JPIP) technique creates precisely patterned hydrophilic domains to act as dedicated water channels, with separate hydrophobic domains for unhindered gas transport. The use of JPIP GDLs dramatically improves fuel cell performance under high current density operation, with important implications for decarbonization via the hydrogen economy.
Electrocardiographic P-Wave Peak Time Predicts Significant İschemia in INOCA Patients: A Pilot Study
(Elsevier B.V., 2025) Ateş, Muhammet Salih; Sökmen, Erdoğan
[Not Abstract Available]
