Synthesis, Antimicrobial, and DNA-Binding Evaluation of Novel Schiff Bases Containing Tetrazole Moiety And Their Ni(II) and Pt(II) Complexes

Abstract

Ni(II) and Pt(II) complexes of tetrazole-containing Schiff bases were synthesized and characterized by physicochemical and various spectroscopic studies. To examine its potential as a candidate anticancer drug, the binding properties of ct-DNA were investigated. The characteristic binding constant (Kb) and binding mode of the complexes with calf thymus DNA (ct-DNA) were determined using absorption titration (1.99 – 76.71 × 104 M-1). According to the kinetic and thermodynamic parameters, the binding constant and spontaneity of the Pt(Tet-SalH) complex were found to be larger. The well-diffusion method was used to deduce the antibacterial potency of Schiff bases and their complexes. All these substances have been examined for antibacterial activity against pathogenic strains and antifungal activity. Only complex [Pt(3,5-Br-Sal-Tet)H2O]Cl∙H2O showed activity against all the microorganisms studied.