Voltammetric Behavior of Telmisartan and Cathodic Adsorptive Stripping Voltammetric Method for Its Assay in Pharmaceutical Dosage Forms and Biological Fluids

Abstract

Electrochemical behavior of Telmisartan and optimum conditions for its assay were investigated by using cyclic voltammetry and square-wave voltammetry. All studies were based on the quasi-reversible and adsorption-controlled electrochemical reduction signal of TS at about -1.50 V versus Ag/AgCl at pH 10.0 in Britton-Robinson buffer. The peak current was found to change linearly with concentration from 1.69 nM (0.87 mu g/L) to 27.5 nM (14.15 mu g/L). The limit of detection and the limit of quantification were found to be 1.05 nM (0.54 mu g/L) and 3.49 nM (1.79 mu g/L), respectively. The method was successfully applied to different samples with good recoveries at about 100%.