The Role of Tyro3-Axl-Mertk Receptors in Uterine Immune Regulation During Pregnancy: A Multilevel Analysis in Mouse Models
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Oxford University Press
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Introduction Successful pregnancy requires immune tolerance and controlled inflammation at the maternal—fetal interface. The Tyro3—Axl—Mertk (TAM) receptor tyrosine kinases and their ligands Gas6 and Protein S modulate immune homeostasis. Their temporal roles in uterine regulation during implantation and decidualization remain unclear. We hypothesized that TAM signaling is essential for establishing uterine tolerance and tissue remodeling.
Açıklama
Anahtar Kelimeler
Animals - Rodent, Molecules - Protein Kinases/Phosphatases, Processes - Reproductive Immunology, Processes - Signal Transduction, Processes - Tolerance/Suppression/Anergy
Kaynak
Journal of Immunology
WoS Q Değeri
Scopus Q Değeri
Cilt
215
Sayı
Künye
Kirimlioglu, E., Okan Oflamaz, A., Orhan, E., Katirci, E., Yıldırım, F., & Demir, N. (2026). The Role of Tyro3—Axl—Mertk Receptors in Uterine Immune Regulation During Pregnancy: A Multilevel Analysis in Mouse Models 2266974. The Journal of Immunology, 215(Supplement_1), vkag141-1114.
