New Antimicrobial Polymeric Microspheres Containing Azomethine

Abstract

Herein, new polymeric microspheres containing azomethine (PS-OPA, PS-OPA-Pt, PS-OPA-Ni, PS-OPA-Mn and PS- OPA-Cu) were synthesized and investigated by elemental analysis, FT-IR, SEM-EDX, TGA-DTA, UV-Vis, GPC and magnetic susceptibility. Antibacterial and antifungal activities of the synthesized polymeric microspheres were evaluated against pathogenic bacteria (Staphylococcus epidermidis ATCC12228, Bacillus cereus RSKK863, Staphylococcus aureus ATCC25923, Enterobacter aerogenes, Pseudomonas aeroginosa sp., Klebsiella pneumonia ATCC27853, Salmonella type H NCTC9018394, Proteus vulgaris RSKK96026, Escherichia coli ATCC1280) and yeast (Candida albicans Y-1200-NIH) by the well-diffusion method for potential biomedical applications. It was determined that polymeric microspheres exhibited higher inhibition effect against B. cereus, E. aerogenes, P. aeruginosa, P. vulgaris and showed higher antifungal activity than standard nystatin.

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