Relationship between Newly Diagnosed Hypertensive Patients' Dipping Status and Mean Neutrophil Volume

Abstract

Objective: Little is known about the pathogenesis of essential hypertension (HT) despite the research conducted in this field. However, similar to other chronic diseases, an association has been shown between HT and inflammation. Thus, this study aimed to explore the association between an indicator of inflammatory response and mean neutrophil volume (MNV) in newly diagnosed hypertensive patients.Materials and Methods: The medical records of patients newly diagnosed with HT were retrospectively reviewed. The control group comprised healthy persons with normal ambulatory blood pressure records. In accordance with their immersion status, newly diagnosed hypertensive patients were divided into two groups.Results: This study included 222 patients: One hundred and forty four patients had HT, and one hundred and eighty-eight were normotensives. HT patients had significantly higher MNV than normotensive patients [144.1 (range: 136.1-152.1 vs.) 140.3 (range: 135.1-145.5), p=0.001], respectively. There were 51 patients with dipper HT and 53 patients with non-dipper HT in the hypertensive group. MNV was significantly higher in the non-dipper HT group [145.7 (range: 138.1-153.46) vs. 142.3 (range: 134.3-150.3), p=0.022], respectively. Multivariate regression analysis demonstrated that MNV [95% confidence interval (CI): 1,006-1,122, p=0.032] and pulse wave velocity (95% CI: 1,203-2,655, p=0.004) were independently correlated with the non-dipping status in newly diagnosed hypertensive patients.Conclusion: Patients with newly diagnosed HT had higher MNV. In addition, increased MNV measurements were associated with non-dipper HT.