Evaluation of The Effects of Pomegranate Juice on Hepato-Nephrotoxicity in Male Rats Exposed to Aluminum

Abstract

We aimed to measure biochemical parameters in rat serum such as electrolyte levels, kidney and liver function test, and lipid profile to analyze the effects of pomegranate juice towards AlCl3-induced hepato-nephrotoxicity. The twenty-eight wistar albino rats divided into four groups; control (Group I), pomegranate juice (4 ml/kg) (Group II), AlCl3 (8.3 mg/kg) (Group III) and pomegranate juice + AlCl3 (Group IV). Aluminum toxicity and the protective effect of pomegranate juice did not statistically different among groups in electrolyte levels, except for Mg and Cl (p<0.05). AlCL3 considerably increased serum AST, ALT, BUN and CREA levels and decreased ALB and TP (p<0.05). Pomegranate juice administration with or before AlCl3 notably restored serum biomarkers of liver and kidney function to near-normal levels. There was only a statistically significant difference in LDL and CHOL levels in lipid metabolism (p<0.05). The pomegranate juice reduced aluminum toxicity in terms of electrolyte levels, liver and renal function test, and lipid profile.