Kırşehir Ahi Evran Üniversitesi Kurumsal Akademik Arşivi
DSpace@Kırşehir, Kırşehir Ahi Evran Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve yayınların etkisimi artırmak için telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Linking Depression, Alcohol Use Disorder, and DYN/KOR System Genes
(Springer Science+Business Media, 2025) Özkan-Kotiloğlu, Selin
Alcohol use disorder (AUD) and depression are comorbid diseases having both individual and social outcomes. While depression is a risk factor for the development of AUD, individuals with AUD are at least twice as likely to suffer from depression. This bidirectional relationship between AUD and depression has been a trigger for investigating underlying mechanisms. These investigations associate the DYN/KOR system, which comprises the kappa opioid receptor (KOR) and its ligand dynorphin (DYN), with both addictive behaviors and negative emotional states. Recent studies have indicated that the effects of the DYN/KOR system in specific brain regions are crucial in the etiology of depression and AUD co-occurrence. This book chapter summarizes the research on DYN/KOR system genes in comorbidity of AUD and depression.
Serum Neuron-Specific Enolase Levels in Patients With Diabetic Peripheral Neuropathy
(John Wiley and Sons Ltd, 2025) Duran, Selcen; Çelikbilek, Asuman; Yetiş, Aysu; İlanbey, Bilal; Şahin, Burç Esra; Köysüren, Aydan; Durmaz, Himmet
Background: Based on previous reports that elevated NSE levels may predict diabetic neuropathy, we aimed to validate this association in a well-characterized cohort. Using strict exclusion criteria, standardized clinical scales, and nerve conduction studies, we aimed to evaluate the clinical utility of NSE levels in diabetic patients with and without neuropathic pain. Methods: A total of 144 Type 2 diabetic patients were included in this prospective cross-sectional study. Neuropathic pain symptoms were assessed using the Douleur Neuropathique 4 questionnaire (DN4) and the Leeds Assessment of Neuropathic Symptoms and Signs (LANSS). The diagnosis of diabetic peripheral neuropathy (DPNP) was established based on electrophysiological findings. Patients were divided into three groups as follows: those having neuropathic pain with DPNP (Group 1, n = 60) and without DPNP (Group 2, n = 56). The patients without neuropathic pain (n = 28) were defined as Group 3. Serum NSE levels were derived via electrochemiluminescence immunoassay. Results: There was no significant between-group difference in age or gender (both p > 0.05). The disease duration was significantly longer in patients having neuropathic pain, compared to those without neuropathic pain (p = 0.004). The serum levels of NSE (p < 0.001) and the scores on the DN4 (p = 0.001) and LANSS (p = 0.016) instruments were higher in Group 1 than in Group 2. The NSE level was positively correlated with the LANSS score (r = 0.260, p = 0.005) and independently associated with the presence of DPNP in a multivariate model (OR 1.33, 95% confidence interval 1.12–1.58, p = 0.001). On the ROC analysis, an NSE cutoff of 9.51 ng/mL predicted the presence of DPNP. Conclusion: Elevated serum NSE levels were significantly associated with DPNP in diabetic patients, indicating that NSE may serve as a potential biomarker for large-fiber involvement. However, this finding warrants confirmation in larger, multicenter studies. Copyright
Evaluation of Mango Production under Climate Change in Türkiye
(Springer Science+Business Media, 2025) Kan, Mustafa; Yaman, Ayşe Feyza; Akan, Kadir; Bahçeci, Melike
Turkiye, traditionally known for its diverse agricultural landscape, has seen an emerging interest in mango cultivation due to favorable climatic conditions in its southern regions. However, climate change poses significant challenges and opportunities for mango production in the country. Shifts in temperature, altered precipitation patterns, and the increasing frequency of extreme weather events are influencing mango phenology, flowering, and fruiting dynamics. Rising temperatures, particularly during critical growth stages, may lead to premature flowering or fruit drop, impacting yield and quality. Meanwhile, erratic rainfall and drought conditions exacerbate water stress and susceptibility to pests and diseases. Despite these challenges, the adaptation of climate-smart agricultural practices such as optimized irrigation, the use of heat- and drought-tolerant cultivars, and the adoption of protective measures like fruit bagging are paving the way for sustainable mango production. This evaluation highlights the necessity for targeted research on varietal adaptation, soil management, and microclimatic interventions in Turkiye. Furthermore, climate-resilient strategies combined with modern cultivation techniques could enhance mango productivity and market potential in the region, aligning with the global demand for this tropical fruit.
The Old Elite Against The New State: The Fall of the Kıbrıslızade Family and Their Struggle with The Committee of Union and Progress
(Routledge, 2026) Korkmaz, Ender; Negiş, Dindar
In 1908, the constitutional revolution led by the Committee of Union and Progress (CUP) brought an end to Sultan Abdülhamid II’s autocratic rule. The restoration of constitutional life created a political vacuum into which multiple elite groups attempted to reassert themselves. Among them was the Kıbrıslızade family–descendants of Grand Vizier Mehmed Emin Pasha–who represented the Istanbul-based ancien régime. This article analyzes the conflict between the Kıbrıslızades, as an example of the traditional elite, and the CUP, which emerged as a new political class composed primarily of organized and ideologically driven military and civil officers of Rumelian origin. Grounded in Gaetano Mosca’s theory of the ‘political class’ and Vilfredo Pareto’s concept of ‘elite circulation’, the study explores how the CUP refused to share state power and employed various instruments, including legal manipulation and political violence, to suppress opposition. The rivalry culminated in the Raid on the Sublime Porte on 23 January 1913, during which Tevfik Bey of the Kıbrıslızade family was killed. Drawing on archival documents, contemporary press, and memoirs, this article examines how elite transformation in the late Ottoman Empire was marked not by a peaceful transition but by a deeply contested and violent power struggle.
Effects of Plyometric Exercise Training with Optimal Drop Heights on Reactive Strength, Maximal Strength, and Vertical Stiffness in Junior Basketball Players: A Randomised Controlled Trial
(Routledge, 2025) Mavili, Caner; Yılmaz, Ekrem; Çelik, Hüseyin; Ünver, Evrim; Arpinar-Avsar, Pinar; Cinemre, Sukru Alpan
This study examined the effects of 8 weeks of low-to-moderate intensity plyometric training with optimal drop heights on maximal isometric strength, vertical stiffness, and reactive strength in junior male basketball players. Participants were randomly divided into training (n = 20) and control (n = 20) groups from 3 teams with same division in the state league. Before and after 8 weeks of training, the drop jump (DJ) and isometric mid-thigh pull (IMTP) tests were performed to evaluate force-time measures. The optimal drop height was determined as the height that provided the highest reactive strength index (RSI). The ground contact phase during the DJ was divided into 2 subphases, braking and propulsion, for a detailed analysis of force-time curves. The analyses revealed that plyometric training significantly improved RSI (p < 0.001, Cohen’s d = 1.507), ground contact (p < 0.001, d=–1.255), braking (p = 0.001, d=–1.066) and propulsion phase (p < 0.001, d=–1.078) time. Significant improvements were observed in the peak vertical ground reaction force (p < 0.001, d = 1.715), peak centre of mass displacement (p = 0.005, d=–0.989), vertical stiffness (p = 0.004, d = 0.983). However, there was no significant difference in the jump height (p = 0.382, d = 0.267) and maximal isometric strength (p = 0.602, d = 0.147). Plyometric training provided improvements in reactive strength, vertical stiffness, but did not improve maximal isometric strength.
